| Entry |
|
|---|
| Name |
Conestat alfa (INN);
Ruconest (TN) |
|---|
| Product |
|
|---|
| Sequence |
NPNATSSSSQ DPESLQDRGE GKVATTVISK MLFVEPILEV SSLPTTNSTT NSATKITANT
TDEPTTQPTT EPTTQPTIQP TQPTTQLPTD SPTQPTTGSF CPGPVTLCSD LESHSTEAVL
GDALVDFSLK LYHAFSAMKK VETNMAFSPF SIASLLTQVL LGAGENTKTN LESILSYPKD
FTCVHQALKG FTTKGVTSVS QIFHSPDLAI RDTFVNASRT LYSSSPRVLS NNSDANLELI
NTWVAKNTNN KISRLLDSLP SDTRLVLLNA IYLSAKWKTT FDPKKTRMEP FHFKNSVIKV
PMMNSKKYPV AHFIDQTLKA KVGQLQLSHN LSLVILVPQN LKHRLEDMEQ ALSPSVFKAI
MEKLEMSKFQ PTLLTLPRIK VTTSQDMLSI MEKLEFFDFS YDLNLCGLTE DPDLQVSAMQ
HQTVLELTET GVEAAAASAI SVARTLLVFE VQQPFLFVLW DQQHKFPVFM GRVYDPRA
(Disulfide bridge: 101-406, 108-183) |
|---|
| Type |
Peptide |
|---|
| Remark |
|
|---|
| Efficacy |
C1 esterase inhibitor |
|---|
| Disease |
Hereditary angioedema [DS: H01006] |
|---|
| Comment |
Treatment of angioedemas, hereditary
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04610 | Complement and coagulation cascades |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B06 OTHER HEMATOLOGICAL AGENTS
B06A OTHER HEMATOLOGICAL AGENTS
B06AC Drugs used in hereditary angioedema
B06AC04 Conestat alfa
D10845 Conestat alfa (INN) <US>
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Serine peptidases
KLKB1
D10845 Conestat alfa (INN) <US>
C1R
D10845 Conestat alfa (INN) <US>
C1S
D10845 Conestat alfa (INN) <US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10845
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
