KEGG   DRUG: OsilodrostatHelp
Entry
D11061                      Drug                                   

Name
Osilodrostat (USAN/INN)
Formula
C13H10FN3
Exact mass
227.0859
Mol weight
227.237
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
ATC code: H02CA02
Chemical structure group: DG02839
Efficacy
Antihypertensive, Steroid 11-beta-hydroxylase inhibitor
Comment
Treatment of Cushing's syndrome
Target
CYP11B2 [HSA:1585] [KO:K07433]
  Pathway
hsa00140  Steroid hormone biosynthesis
hsa04925  Aldosterone synthesis and secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02C ANTIADRENAL PREPARATIONS
    H02CA Anticorticosteroids
     H02CA02 Osilodrostat
      D11061  Osilodrostat (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP11B2
     D11061  Osilodrostat (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 928134-65-0
PubChem: 363669774
ChEMBL: CHEMBL3099695
LinkDB All DBs
KCF data Show

ATOM        17
            1   C8x C    13.7900  -12.3200
            2   C8y C    13.7900  -13.7200
            3   C8y C    15.0024  -14.4200
            4   C8x C    16.2149  -13.7200
            5   C8x C    16.2149  -12.3200
            6   C8y C    15.0024  -11.6200
            7   C3b C    15.0024  -10.2202
            8   N3a N    15.0024   -8.8202
            9   X   F    12.5776  -14.4200
            10  C1y C    15.0024  -15.8198
            11  C1x C    13.8552  -16.6535
            12  C1x C    14.2936  -18.0023
            13  C8y C    15.7118  -18.0021
            14  N4y N    16.1499  -16.6533
            15  C8x C    16.8593  -18.8356
            16  N5x N    18.0065  -18.0018
            17  C8x C    17.5681  -16.6531
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 3
            9     2   9 1
            10   10   3 1 #Down
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16   13  15 2
            17   15  16 1
            18   16  17 2
            19   14  17 1

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