KEGG   DRUG: Pegvaliase
Entry
D11077                      Drug                                   

Name
Pegvaliase (INN);
Pegvaliase-pqpz;
Palynziq (TN)
Product
Sequence
MKTLSQAQSK TSSQQFSFTG NSSANVIIGN QKLTINDVAR VARNGTLVSL TNNTDILQGI
QASCDYINNA VESGEPIYGV TSGFGGMANV AISREQASEL QTNLVWFLKT GAGNKLPLAD
VRAAMLLRAN SHMRGASGIR LELIKRMEIF LNAGVTPYVY EFGSIGASGD LVPLSYITGS
LIGLDPSFKV DFNGKEMDAP TALRQLNLSP LTLLPKEGLA MMNGTSVMTG IAANCVYDTQ
ILTAIAMGVH ALDIQALNGT NQSFHPFIHN SKPHPGQLWA ADQMISLLAN SQLVRDELDG
KHDYRDHELI QDRYSLRCLP QYLGPIVDGI SQIAKQIEIE INSVTDNPLI DVDNQASYHG
GNFLGQYVGM GMDHLRYYIG LLAKHLDVQI ALLASPEFSN GLPPSLLGNR ERKVNMGLKG
LQICGNSIMP LLTFYGNSIA DRFPTHAEQF NQNINSQGYT SATLARRSVD IFQNYVAIAL
MFGVQAVDLR TYKKTGHYDA RASLSPATER LYSAVRHVVG QKPTSDRPYI WNDNEQGLDE
HIARISADIA AGGVIVQAVQ DILPSLH
  Type
Peptide
Remark
ATC code: A16AB19
Product: D11077<US>
Efficacy
Antihyperphenylalaninemia
  Disease
Phenylketonuria [DS:H00167]
Comment
Phenylalanine ammonia lyase (PAL) derived from Anabaena variabilis
Reduction of high blood phenylalanine concentrations caused by PAH deficiency
Target
PAH* [HSA_VAR:5053v1] [HSA:5053] [KO:K00500]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB19 Pegvaliase
      D11077  Pegvaliase (INN) <US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Pegvaliase
   D11077  Pegvaliase (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Other monooxygenases
    PAH* [HSA_VAR:5053v1]
     D11077  Pegvaliase (INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11077
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11077
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11077
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D11077
Other DBs
CAS: 1585984-95-7
PubChem: 375581024
LinkDB

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