KEGG   DRUG: Trevogrumab
Entry
D11242                      Drug                                   
Name
Trevogrumab (USAN/INN)
Formula
C6374H9884N1696O2018S46
Exact mass
143947.0091
Mol weight
144035.8232
Sequence
(Heavy chain)
EVQVLESGGD LVQPGGSLRL SCAASGFTFS AYAMTWVRQA PGKGLEWVSA ISGSGGSAYY
ADSVKGRFTI SRDNSKNTVY LQMNSLRAED TAVYYCAKDG AWKMSGLDVW GQGTTVIVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPPCP APEFLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
NVFSCSVMHE ALHNHYTQKS LSLSLGK
(Light chain)
DIQMTQSPAS LSASVGDRVT ITCRASQDIS DYLAWYQQKP GKIPRLLIYT TSTLQSGVPS
RFRGSGSGTD FTLTISSLQP EDVATYYCQK YDSAPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H134-L214, H147-H203, H226-H'226, H229-H'229, H261-H321, H367-H425, H'22-H'96, H'134-L'214, H'147-H'203, H'261-H'321, H'367-H'425, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Myostatin inhibitor
  Type
Monoclonal antibody
Comment
Treatment of muscle atrophy due to orthopedic disuse and sarcopenia
Target
MSTN [HSA:2660] [KO:K05497]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Transforming growth factors (RSTK-binding)
    MSTN
     D11242  Trevogrumab (USAN/INN)
Other DBs
CAS: 1429201-24-0
PubChem: 384585220
LinkDB

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