KEGG   DRUG: Taldefgrobep alfa
Entry
D11265                      Drug                                   
Name
Taldefgrobep alfa (USAN/INN);
Talditercept alfa (USAN)
Formula
C3386H5242N882O1048S16
Exact mass
75539.9538
Mol weight
75586.19
Sequence
DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD
GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK
GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS
DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPELQLE ESAAEAQEGE
LEGVSDVPRD LEVVAATPTS LLISWTLPHA GRAHYYRITY GETGGNSPVQ EFTVPGRGVT
ATISGLKPGV DYTITVYAVT VTTTKVIHYK PISINYRTEI
(Disulfide bridge: 6-6', 9-9', 41-101, 41'-101', 147-205, 147'-205')
  Type
Peptide
Efficacy
Myostatin inhibitor
Comment
Treatment of ALS, Duchenne muscular dystrophy and spinal muscular atrophy
Target
MSTN [HSA:2660] [KO:K05497]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Transforming growth factors (RSTK-binding)
    MSTN
     D11265  Taldefgrobep alfa (USAN/INN)
Other DBs
CAS: 1580555-26-5
PubChem: 384585243
LinkDB

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