KEGG   DRUG: OlendalizumabHelp
Entry
D11331                      Drug                                   

Name
Olendalizumab (USAN);
Lendalizumab
Formula
C6538H10060N1716O2132S56
Exact mass
148515.5887
Mol weight
148607.691
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT DYSMDWVRQA PGQGLEWMGA IHLNTGYTNY
NQKFKGRVTM TRDTSTSTVY MELSSLRSED TAVYYCARGF YDGYSPMDYW GQGTTVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER KCCVECPPCP APPVAGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSQEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKGLPSS IEKTISKAKG QPREPQVYTL PPSQEEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSRLT VDKSRWQEGN
VFSCSVMHEA LHNHYTQKSL SLSLGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASESVD SYGNSFMHWY QQKPGKAPKL LIYRASNLES
GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCQQSNEDPY TFGGGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H96, H134-L218, H147-H203, H222-H'222, H223-H'223, H226-H'226, H229-H'229, H260-H320, H366-H424, H'22-H'96, H'134-L'218, H'147-H'203, H'260-H'320, H'366-H'424, L23-L92, L138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Efficacy
Anti-inflammatory, Anti-complement C5a antibody
Comment
Monoclonal antibody
Treatment of inflammatory conditions including systemic lupus erythematosus (SLE) and/or lupus nephritis (LN), acute graft versus host disease involving the gastrointestinal tract, and antiphospholipid syndrome
Target
C5 (C5a) [HSA:727] [KO:K03994]
  Pathway
hsa04610  Complement and coagulation cascades
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    C5 (C5a)
     D11331  Olendalizumab (USAN)
BRITE hierarchy
Other DBs
CAS: 1337966-73-0
PubChem: 384585309
LinkDB All DBs

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