KEGG   DRUG: Elezanumab
Entry
D11355                      Drug                                   
Name
Elezanumab (USAN/INN)
Formula
C6348H9820N1684O2016S46
Exact mass
143370.4816
Mol weight
143459.04
Sequence
(Heavy chain)
EVQLVQSGAE VKKPGASVKV SCKASGYTFT SHGISWVRQA PGQGLDWMGW ISPYSGNTNY
AQKLQGRVTM TTDTSTSTAY MELSSLRSED TAVYYCARVG SGPYYYMDVW GQGTLVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPEAAGG
PSVFLFPPKP KDQLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE
MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV LHEALHNHYT QKSLSLSPGK
(Light chain)
QSALTQPRSV SGSPGQSVTI SCTGTSSSVG DSIYVSWYQQ HPGKAPKLML YDVTKRPSGV
PDRFSGSKSG NTASLTISGL QAEDEADYYC YSYAGTDTLF GGGTKVTVLG QPKAAPSVTL
FPPSSEELQA NKATLVCLIS DFYPGAVTVA WKADSSPVKA GVETTTPSKQ SNNKYAASSY
LSLTPEQWKS HRSYSCQVTH EGSTVEKTVA PTECS
(Disulfide bridge: H22-H96, H147-H203, H223-L214, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'96, H'147-H'203, H'223-L'214, H'264-H'324, H'370-H'428, L22-L90, L137-L196, L'22-L'90, L'137-L'196)
  Type
Peptide
Efficacy
Neuroprotectant, Anti-repulsive guidance molecule RGMa antibody
  Type
Monoclonal antibody
Comment
Treatment of spinal cord injury and multiple sclerosis
Target
RGMA [HSA:56963] [KO:K23096]
  Pathway
hsa04350  TGF-beta signaling pathway
hsa04360  Axon guidance
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Nervous system
    RGMA
     D11355  Elezanumab (USAN/INN)
Other DBs
CAS: 1791416-49-3
PubChem: 384585333
LinkDB

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