KEGG   DRUG: LifirafenibHelp
Entry
D11410                      Drug                                   

Name
Lifirafenib (USAN/INN)
Formula
C25H17F3N4O3
Exact mass
478.1253
Mol weight
478.4227
Structure
Mol fileKCF fileDB search
Remark
Chemical structure group: DG03009
Efficacy
Antineoplastic
Target
BRAF [HSA:673] [KO:K04365]
EGFR [HSA:1956] [KO:K04361]
  Pathway
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   TKL group
    BRAF
     D11410  Lifirafenib (USAN/INN)
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR
     D11410  Lifirafenib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 1446090-79-4
PubChem: 384585388
ChEMBL: CHEMBL4111470
PDB-CCD: 3K3[PDBj]
LinkDB All DBs
KCF data Show

ATOM        35
            1   C8x C     5.8800  -16.9400
            2   C8y C     5.8800  -18.3400
            3   C8x C     7.0700  -19.0400
            4   C8y C     8.3300  -18.3400
            5   C8y C     8.3300  -16.9400
            6   C8x C     7.0700  -16.2400
            7   C1d C     4.6900  -19.0400
            8   N5x N     9.6600  -18.7600
            9   C8y C    10.4300  -17.6400
            10  N4x N     9.6600  -16.5200
            11  C1y C    11.8300  -17.6400
            12  C8y C    14.4900  -15.6100
            13  C8y C    14.4900  -17.0100
            14  C8x C    15.6800  -17.7100
            15  C8y C    16.9400  -17.0100
            16  C8x C    16.9400  -15.6100
            17  C8x C    15.6800  -14.9100
            18  O2x O    13.1600  -15.1900
            19  C1y C    12.3200  -16.3100
            20  C1y C    13.1600  -17.4300
            21  O2a O    18.1300  -17.7100
            22  C8y C    19.3900  -17.0100
            23  C8x C    19.3900  -15.6100
            24  C8y C    20.5800  -17.7100
            25  C8y C    21.8400  -17.0100
            26  N5x N    21.8400  -15.6100
            27  C8x C    20.5800  -14.9100
            28  C1x C    20.5800  -19.1100
            29  C1x C    21.7700  -19.8100
            30  C5x C    23.0300  -19.1100
            31  N1x N    23.0300  -17.7100
            32  O5x O    24.2200  -19.8800
            33  X   F     3.5000  -19.7400
            34  X   F     3.9900  -17.8500
            35  X   F     5.3900  -20.2300
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     4   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12   11   9 1 #Down
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   12  17 1
            19   12  18 1
            20   18  19 1
            21   19  20 1
            22   20  13 1 #Up
            23   11  20 1
            24   19  11 1
            25   15  21 1
            26   21  22 1
            27   23  22 2
            28   22  24 1
            29   24  25 2
            30   25  26 1
            31   26  27 2
            32   23  27 1
            33   24  28 1
            34   28  29 1
            35   29  30 1
            36   30  31 1
            37   25  31 1
            38   30  32 2
            39    7  33 1
            40    7  34 1
            41    7  35 1

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