KEGG   DRUG: Nimacimab
Entry
D11435                      Drug                                   

Name
Nimacimab (USAN)
Formula
C6440H9914N1714O2014S44
Exact mass
144893.3754
Mol weight
144982.7606
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYEFS YYWMNWVRQA PGQGLEWMGQ IYPGDGETKY
AQKFQGRVTI TADKSTSTAY MELSSLRSED TAVYYCARSH GNYLPYWGQG TLVTVSSAST
KGPSVFPLAP CSRSTSESTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTKTYTC NVDHKPSNTK VDKRVESKYG PPCPPCPAPE FLGGPSVFLF
PPKPKDTLMI SRTPEVTCVV VDVSQEDPEV QFNWYVDGVE VHNAKTKPRE EQFNSTYRVV
SVLTVLHQDW LNGKEYKCKV SNKGLPSSIE KTISKAKGQP REPQVYTLPP SQEEMTKNQV
SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSRLTVD KSRWQEGNVF
SCSVMHEALH NHYTQKSLSL SLGK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS SSYLHWYQQK PGQAPRLLIY STSNLASGIP
ARFSGSGSGT DFTLTISRLE PEDFAVYYCH QYHRSPPTFG QGTKVEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H131-L215, H144-H200, H223-H'223, H226-H'226, H258-H318, H364-H422, H'22-H'96, H'131-L'215, H'144-H'200, H'258-H'318, H'364-H'422, L23-L89, L135-L195, L'23-L'89, L'135-L'195)
  Type
Peptide
Efficacy
Anti-inflammatory
Comment
Monoclonal antibody
Treatment of non-alcoholic steatohepatitis (NASH) and other cardiometabolic diseases associated with dysregulation of the endocannabinoid system (ECS)
Target
CNR1 [HSA:1268] [KO:K04277]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Cannabinoid
    CNR1
     D11435  Nimacimab (USAN)
Other DBs
CAS: 2098636-09-8
PubChem: 384585412
LinkDB

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