KEGG   DRUG: Nomacopan
Entry
D11473                      Drug                                   

Name
Nomacopan (USAN)
Formula
C720H1107N197O244S11
Exact mass
16768.7198
Mol weight
16779.3821
Sequence
DSESDCTGSE PVDAFQAFSE GKEAYVLVRS TDPKARDCLK GEPAGEKQDN TLPVMMTFKN
GTDWASTDWT FTLDGAKVTA TLGNLTQNRE VVYDSQSHHC HVDKVEKEVP DYEMWMLDAG
GLEVEVECCR QKLEELASGR NQMYPHLKDC
(Disulfide bridge: 6-128, 38-150, 100-129)
  Type
Peptide
Efficacy
Anti-inflammatory, Complement C5 inhibitor
Comment
Treatment of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome and Guillain-Barre syndrome
Target
C5 [HSA:727] [KO:K03994]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Complement and coagulation
    C5
     D11473  Nomacopan (USAN)
Other DBs
CAS: 875125-19-2
PubChem: 384585449
LinkDB

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