KEGG   DRUG: Terazosin hydrochloride anhydrous
Entry
D11585                      Drug                                   

Name
Terazosin hydrochloride anhydrous
Product
  Generic
Formula
C19H25N5O4. HCl
Exact mass
423.1673
Mol weight
423.8938
Structure
Remark
Chemical structure group: DG00491
Product (DG00491): D00610<JP/US> D11585<US>
Efficacy
Antidysuria, Antihypertensive, alpha1-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Prazosin derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D11585  Terazosin hydrochloride anhydrous <US>
Other DBs
CAS: 63074-08-8
PubChem: 405226452
ChEMBL: CHEMBL1256665
LinkDB
KCF data

ATOM        29
            1   C8y C    18.0600  -17.9200
            2   C8y C    18.0600  -16.5200
            3   C8x C    19.2500  -18.6200
            4   C8y C    16.8700  -18.6200
            5   N5x N    16.8700  -15.8200
            6   C8x C    19.2500  -15.8200
            7   C8y C    20.5100  -17.9200
            8   N5x N    15.6100  -17.9200
            9   N1a N    16.8700  -20.0200
            10  C8y C    15.6100  -16.5200
            11  C8y C    20.5100  -16.5200
            12  O2a O    21.7000  -18.6200
            13  N1y N    14.4200  -15.8200
            14  O2a O    21.7000  -15.8200
            15  C1a C    22.8900  -17.9200
            16  C1x C    14.4200  -14.4200
            17  C1x C    13.2300  -16.5200
            18  C1a C    22.8900  -16.5200
            19  C1x C    13.2300  -13.7200
            20  C1x C    11.9700  -15.8200
            21  N1y N    11.9700  -14.4200
            22  C5a C    10.7800  -13.7200
            23  C1y C     9.5900  -14.4200
            24  O5a O    10.7800  -12.3200
            25  C1x C     9.5900  -15.8200
            26  O2x O     8.2600  -14.0000
            27  C1x C     7.4200  -15.1200
            28  C1x C     8.2600  -16.2400
            29  X   Cl   23.4500  -12.2500
BOND        31
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21    7  11 1
            22    8  10 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 2
            27   23  25 1
            28   23  26 1
            29   26  27 1
            30   27  28 1
            31   25  28 1

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