Entry |
|
Name |
Venglustat (USAN/INN) |
Formula |
C20H24FN3O2S
|
Exact mass |
389.1573
|
Mol weight |
389.49
|
Structure |

|
Remark |
|
Efficacy |
Glucosylceramide synthase inhibitor |
Comment |
Treatment of Fabry disease (FD), Gaucher disease type 3 (GD3), Glucocerebrosidase gene-associated Parkinson disease (GBA-PD) and Autosomal dominant polycystic kidney disease (ADPKD)
|
Target |
|
Pathway |
|
Brite |
Target-based classification of drugs [BR:br08310]
Enzymes
Transferases (EC2)
Hexosyltransferases
UGCG
D11633 Venglustat (USAN/INN)
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 27
1 C1x C 22.7500 -17.5700
2 C1x C 22.7500 -16.1700
3 C1y C 21.5600 -15.4700
4 C1y C 20.3000 -16.1700
5 C1x C 20.3000 -17.5700
6 N1y N 21.5600 -18.2700
7 O7a O 19.1100 -15.4700
8 C7a C 17.9200 -16.1700
9 N1b N 16.7300 -15.4700
10 O6a O 17.9200 -17.5700
11 C1d C 15.5400 -16.1700
12 C8y C 14.3500 -15.4700
13 C1a C 14.8400 -17.3600
14 C1a C 16.2400 -17.3600
15 C8x C 13.8600 -14.1400
16 S2x S 12.4600 -14.1400
17 C8y C 12.0400 -15.4700
18 N5x N 13.2300 -16.3100
19 C8y C 10.8500 -16.1700
20 C8x C 9.6600 -15.4700
21 C8x C 8.4000 -16.1700
22 C8y C 8.4000 -17.5700
23 C8x C 9.5900 -18.2700
24 C8x C 10.8500 -17.5700
25 X F 7.2100 -18.2700
26 C1x C 21.2100 -16.9400
27 C1x C 22.2600 -16.6600
BOND 30
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1 #Up
8 7 8 1
9 8 9 1
10 8 10 2
11 9 11 1
12 11 12 1
13 11 13 1
14 11 14 1
15 12 15 2
16 15 16 1
17 16 17 1
18 17 18 2
19 12 18 1
20 17 19 1
21 19 20 2
22 20 21 1
23 21 22 2
24 22 23 1
25 23 24 2
26 19 24 1
27 22 25 1
28 6 26 1
29 3 27 1
30 27 26 1
|