Entry |
|
Name |
Clazosentan (USAN/INN) |
Formula |
C25H23N9O6S
|
Exact mass |
577.1492
|
Mol weight |
577.5718
|
Structure |
|
Class |
Cardiovascular agent
DG01502 Endothelin receptor antagonist
|
Remark |
Product (DG03076): | D07682<JP> |
|
Efficacy |
Vasodilator, Endothelin receptor type A antagonist |
Comment |
Treatment of aneurysmal subarachnoid hemorrhage
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
hsa04270 | Vascular smooth muscle contraction |
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C04 PERIPHERAL VASODILATORS
C04A PERIPHERAL VASODILATORS
C04AX Other peripheral vasodilators
C04AX33 Clazosentan
D11664 Clazosentan (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01502 Endothelin receptor antagonist
DG03076 Clazosentan
D11664 Clazosentan
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Endothelin
EDNRA
D11664 Clazosentan (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01502 Endothelin receptor antagonist
DG03076 Clazosentan
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 41
1 C8y C 16.2400 -12.0400
2 N5x N 15.0500 -11.3400
3 C8x C 13.7900 -12.0400
4 C8y C 13.7900 -13.4400
5 C8x C 15.0500 -14.1400
6 C8x C 16.2400 -13.4400
7 N5x N 17.4300 -14.1400
8 C8y C 18.6900 -13.4400
9 N1b N 18.6900 -12.0400
10 O2a O 21.0700 -16.2400
11 C1b C 21.0700 -17.6400
12 C1b C 22.1900 -18.3400
13 O1a O 23.3800 -17.6400
14 C8x C 23.3800 -16.2400
15 C8x C 22.1900 -15.5400
16 C8y C 16.2400 -16.2400
17 C8x C 15.0500 -15.5400
18 C8x C 13.7900 -16.2400
19 N5x N 13.7900 -17.6400
20 C8y C 15.0500 -18.3400
21 C8x C 16.2400 -17.6400
22 C8y C 17.4300 -15.5400
23 N5x N 18.6200 -16.2400
24 C8y C 22.1900 -14.1400
25 C8x C 24.5700 -15.5400
26 C8x C 24.5700 -14.1400
27 C8y C 23.3800 -13.4400
28 C8y C 19.8800 -14.1400
29 C8y C 19.8800 -15.5400
30 O2a O 21.0700 -13.4400
31 O2a O 23.3800 -12.0400
32 C1a C 12.6000 -14.1400
33 O3c O 18.5500 -10.5000
34 C1a C 24.6400 -11.3400
35 S4a S 17.4300 -11.3400
36 O3c O 16.1000 -10.5000
37 C8y C 15.0500 -19.7400
38 N5x N 13.9300 -20.5800
39 N5x N 14.3500 -21.9100
40 N5x N 15.8200 -21.9100
41 N4x N 16.1700 -20.5100
BOND 45
1 19 20 2
2 20 21 1
3 21 16 2
4 2 3 2
5 3 4 1
6 22 16 1
7 23 22 2
8 4 5 2
9 5 6 1
10 6 1 2
11 24 15 1
12 14 25 1
13 25 26 2
14 26 27 1
15 27 24 2
16 10 11 1
17 11 12 1
18 12 13 1
19 28 29 2
20 29 10 1
21 24 30 1
22 30 28 1
23 7 22 1
24 23 29 1
25 28 8 1
26 14 15 2
27 27 31 1
28 4 32 1
29 1 2 1
30 7 8 2
31 8 9 1
32 9 35 1
33 35 33 2
34 35 1 1
35 31 34 1
36 16 17 1
37 17 18 2
38 35 36 2
39 18 19 1
40 20 37 1
41 38 39 1
42 39 40 2
43 40 41 1
44 37 41 1
45 37 38 2
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