KEGG   DRUG: Nipocalimab
Entry
D11666                      Drug                                   
Name
Nipocalimab (USAN);
Nipocalimab (genetical recombination) (JAN);
Nipocalimab-aahu;
Imaavy (TN)
Product
Formula
C6266H9722N1670O1992S46
Exact mass
141707.7937
Mol weight
141795.31
Sequence
(Heavy chain)
EVQLLESGGG LVQPGGSLRL SCAASGFTFS TYAMGWVRQA PGKGLEWVSS IGASGSQTRY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARLA IGDSYWGQGT MVTVSSASTK
GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS
LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PELLGGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYASTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN
VFSCSVMHEA LHNHYTQKSL SLSPG
(Light chain)
QSALTQPASV SGSPGQSITI SCTGTGSDVG SYNLVSWYQQ HPGKAPKLMI YGDSERPSGV
SNRFSGSKSG NTASLTISGL QAEDEADYYC SSYAGSGIYV FGTGTKVTVL GQPKAAPSVT
LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK AGVETTTPSK QSNNKYAASS
YLSLTPEQWK SHKSYSCQVT HEGSTVEKTV APTECS
(disulfide bridge: H22-H96, H143-H199, H219-L215, H225-H'225, H228-H'228, H260-H320, H366-H424, H'22-H'96, H'143-H'199, H'219-L'215, H'260-H'320, H'366-H'424, L22-L90, L138-L197, L'22-L'90, L'138-L'197)
  Type
Peptide
Remark
Therapeutic category: 6399
ATC code: L04AL03
Product: D11666<JP/US>
Efficacy
Autoimmune disease treatment, Anti-Fc receptor antibody
  Disease
Generalized myasthenia gravis (anti-acetylcholine receptor antibody positive) [DS:H01594]
Generalized myasthenia gravis (anti-muscle-specific tyrosine kinase antibody positive) [DS:H01594]
  Type
Monoclonal antibody
Comment
Treatment of diseases mediated by pathogenic IgG autoantibodies and alloantibodies
Target
FCGRT [HSA:2217] [KO:K24019]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AL Neonatal fragment crystallizable receptor (FcRn) inhibitors
     L04AL03 Nipocalimab
      D11666  Nipocalimab (USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D11666  Nipocalimab (USAN); Nipocalimab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Immune system
    FCGRT
     D11666  Nipocalimab (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11666
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11666
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11666
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11666
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D11666
Other DBs
CAS: 2211985-36-1
PubChem: 405226533
LinkDB

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