KEGG   DRUG: Miricorilant
Entry
D11667                      Drug                                   

Name
Miricorilant (USAN/INN)
Formula
C24H23F3N2O2
Exact mass
428.1712
Mol weight
428.4468
Structure
Efficacy
Glucocorticoid receptor modulator, Mineralocorticoid receptor antagonist
Comment
Treatment of metabolic disorders, especially antipsychotic-induced weight gain
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
NR3C2 (MR) [HSA:4306] [KO:K08555]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04960  Aldosterone-regulated sodium reabsorption
Brite
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D11667  Miricorilant (USAN/INN)
    NR3C2 (MR)
     D11667  Miricorilant (USAN/INN)
Other DBs
CAS: 1400902-13-7
PubChem: 405226534
ChEMBL: CHEMBL4297602
LinkDB
KCF data

ATOM        31
            1   N4x N    21.0398  -14.0489
            2   C8y C    21.0398  -15.4465
            3   C8y C    19.8518  -16.1453
            4   C8y C    18.5940  -15.4465
            5   N4x N    18.5940  -14.0489
            6   C8y C    19.8518  -13.3501
            7   O5x O    19.8518  -11.9525
            8   C1b C    19.8518  -17.5429
            9   C8y C    21.0398  -18.2417
            10  C8x C    22.2277  -17.5429
            11  C8y C    23.4856  -18.2417
            12  C8x C    23.4856  -19.6393
            13  C8x C    22.2976  -20.3381
            14  C8x C    21.0398  -19.6393
            15  O5x O    22.2277  -16.1453
            16  C1d C    24.6735  -17.5429
            17  X   F    25.9314  -16.8441
            18  X   F    25.3723  -18.7308
            19  X   F    23.9747  -16.3549
            20  C1y C    17.4060  -16.1453
            21  C1x C    17.4060  -17.5429
            22  C1x C    16.1482  -18.2417
            23  C1y C    14.9602  -17.5429
            24  C1x C    14.9602  -16.1453
            25  C1x C    16.1482  -15.4465
            26  C8y C    13.7722  -18.2417
            27  C8x C    13.7722  -19.6393
            28  C8x C    12.5144  -20.3381
            29  C8x C    11.3264  -19.6393
            30  C8x C    11.3264  -18.2417
            31  C8x C    12.5144  -17.5429
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 2
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16    2  15 2
            17   11  16 1
            18   16  17 1
            19   16  18 1
            20   16  19 1
            21   20   4 1 #Up
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   20  25 1
            28   23  26 1 #Down
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   26  31 1

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