KEGG   DRUG: Ianalumab
Entry
D12151                      Drug                                   
Name
Ianalumab (USAN/INN)
Formula
C6606H10224N1740O2098S40
Exact mass
148777.5656
Mol weight
148868.93
Sequence
(Heavy chain)
XVQLQQSGPG LVKPSQTLSL TCAISGDSVS SNSAAWGWIR QSPGRGLEWL GRIYYRSKWY
NSYAVSVKSR ITINPDTSKN QFSLQLNSVT PEDTAVYYCA RYDWVPKIGV FDSWGQGTLV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK RVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SREEMTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPG
(Light chain)
DIVLTQSPAT LSLSPGERAT LSCRASQFIS SSYLSWYQQK PGQAPRLLIY GSSSRATGVP
ARFSGSGSGT DFTLTISSLE PEDFAVYYCQ QLYSSPMTFG QGTKVEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H99, H227-L215, H151-H207, H233-H'233, H236-H'236, H268-H328, H374-H432, H'22-H'99, H'227-L'215, H'151-H'207, H'268-H'328, H'374-H'432, L23-L89, L135-L195, L'23-L'89, L'135-L'195)
  Type
Peptide
Efficacy
Immunomodulator
  Type
Monoclonal antibody
Comment
Treatment of autoimmune diseases and cancer immunotherapy
Target
TNFRSF13C (BAFF-R, CD268) [HSA:115650] [KO:K05151]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF13C (BAFF-R, CD268)
     D12151  Ianalumab (USAN/INN)
Other DBs
CAS: 1929549-92-7
PubChem: 497620564
LinkDB

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