KEGG   DRUG: イブプロフェン
エントリ  
D00126                      Drug                                   

一般名   
イブプロフェン (JP17);
Ibuprofen (JP17/USP/INN)
商品名   
  後発品
米国の商品 
  後発品
IBU (RedPharm Drug), IBU (RedPharm Drug), IBU (RedPharm Drug), IBUPROFEN (DIRECT RX), IBUPROFEN (Direct_Rx), IBU (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBU (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBU (A-S Medication Solutions), IBU (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (Actavis Pharma), IBUPROFEN (AiPing Pharmaceutical), IBUPROFEN (AiPing Pharmaceutical), IBUPROFEN (American Health Packaging), IBUPROFEN (American Health Packaging), IBUPROFEN (Amneal Pharmaceuticals LLC), IBUPROFEN (Amneal Pharmaceuticals NY LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBU (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Ascend Laboratories), IBUPROFEN (Ascend Laboratories), IBUPROFEN (Aurobindo Pharma Limited), IBUPROFEN (AvKARE), IBUPROFEN (AvKARE), IBUPROFEN (AvKARE), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (DIRECTRX), IBUPROFEN (Denton Pharma), IBUPROFEN (Denton Pharma), IBUPROFEN (Denton Pharma), IBU (Denton Pharma), IBUPROFEN (Denton Pharma), IBUPROFEN (Denton Pharma), IBUPROFEN (Direct_Rx), IBUPROFEN (Direct_Rx), IBUPROFEN (Direct_Rx), IBU (Dr. Reddy's Laboratories Limited), IBUPROFEN (Granules India Limited), IBUPROFEN (Hi-Tech Pharmacal), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Legacy Pharmaceutical Packaging), IBUPROFEN (MARKSANS PHARMA LIMITED), IBUPROFEN (Major Pharmaceuticals), IBUPROFEN (McKesson Corporation dba SKY Packaging), IBUPROFEN (Medsource Pharmaceuticals), IBUPROFEN (Method Pharmaceuticals), IBU (NCS HealthCare of KY), IBUPROFEN (NCS HealthCare of KY), IBUPROFEN (NCS HealthCare of KY), IBUPROFEN (Northwind Pharmaceuticals), IBUPROFEN (Northwind Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticalsf), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (Perrigo New York), IBUPROFEN (PharmPak), IBUPROFEN (PharmPak), IBUPROFEN (PharmPak), IBUPROFEN (Pharmaceutical Associates), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBU (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPAK (PureTek Corporation), IBUPROFEN (QPharma), IBUPROFEN (QPharma), IBUPROFEN (QPharma), IBUPROFEN (QPharma), IBUPROFEN (Quality Care Products), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBU (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBU (St. Mary's Medical Park Pharmacy), IBU (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (Strides Pharma), IBUPROFEN (Strides Pharma Science Limited), IBUPROFEN (Sunshine Lake Pharma), IBUPROFEN (TIME CAP LABORATORIES), IBUPROFEN (Taro Pharmaceuticals U.S.A.), IBUPROFEN (Unit Dose Services), IBUPROFEN (Unit Dose Services), IBU (Unit Dose Services), IBU (Unit Dose Services), IBUPROFEN (VistaPharm), IBUPROFEN (medsource pharmaceuticals), IBUPROFEN (Aurobindo Pharma Limited)
組成式   
C13H18O2
質量    
206.1307
分子量   
206.2808
構造式   
Simcomp   
クラス   
抗炎症薬
 DG01908  プロピオン酸系抗炎症薬
 DG01504  非ステロイド性抗炎症薬 (NSAID)
  DG01908  プロピオン酸系抗炎症薬
代謝酵素基質薬
 DG01642  CYP2C9基質薬
コード   
同一コード: C01588
薬効分類: 1149
ATCコード: C01EB16 G02CC01 M01AE01 M02AA13 R02AX02
化学構造グループ: DG00245
商品 (DG00245): D00126<JP/US> D01122<JP> D06606<JP/US>
商品 (mixture): D02152<US> D11573<US> D11575<US>
効能    
鎮痛薬, 抗炎症薬, 解熱薬, シクロオキシゲナーゼ阻害薬
  疾患
関節リウマチ [DS:H00630]
コメント  
プロピオン酸誘導体
ターゲット 
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  パスウェイ
hsa00590  アラキドン酸の代謝
代謝    
Enzyme: CYP2C9 [HSA:1559]
相互作用  

構造マップ 
map07048  抗片頭痛薬
map07219  シクロオキシナーゼ (COX) 阻害薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   114  解熱鎮痛消炎剤
    1149  その他の解熱鎮痛消炎剤
     D00126  イブプロフェン (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C01 心疾患治療
   C01E その他の心疾患用製剤
    C01EB その他の心疾患用製剤
     C01EB16 イブプロフェン
      D00126  イブプロフェン (JP17) <JP/US>
 G 泌尿生殖器系と性ホルモン
  G02 その他の婦人科用薬
   G02C その他の婦人科用薬
    G02CC 膣内投与用抗炎症製剤
     G02CC01 イブプロフェン
      D00126  イブプロフェン (JP17) <JP/US>
 M 筋骨格系
  M01 抗炎症及び抗リウマチ製剤
   M01A 抗炎症及び抗リウマチ製剤、非ステロイド系
    M01AE プロピオン酸誘導体
     M01AE01 イブプロフェン
      D00126  イブプロフェン (JP17) <JP/US>
  M02 関節・筋肉痛用局所薬剤
   M02A 関節・筋肉痛用局所薬剤
    M02AA 抗炎症製剤、局所用非ステロイド系
     M02AA13 イブプロフェン
      D00126  イブプロフェン (JP17) <JP/US>
 R 呼吸器系
  R02 咽頭用製剤
   R02A 咽頭用製剤
    R02AX その他の咽頭用製剤
     R02AX02 イブプロフェン
      D00126  イブプロフェン (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 鎮痛薬
  非ステロイド系抗炎症薬
   イブプロフェン
    D00126  イブプロフェン (JP17)
一般用医薬品の分類 [BR:jp08313]
 精神神経用薬
  01 かぜ薬(内用)
   D00126  イブプロフェン (JP17)
  03 解熱鎮痛薬
   D00126  イブプロフェン (JP17)
一般用医薬品のリスク区分 [BR:jp08312]
 指定第二類
  無機薬品及び有機薬品
   イブプロフェン
    D00126  イブプロフェン (JP17)
 第二類
  無機薬品及び有機薬品
   イブプロフェン
    D00126  イブプロフェン (JP17)
ターゲットに基づく医薬品分類 [BR:jp08310]
 酵素
  オキシドレダクターゼ (EC1)
   プロスタグランジン合成酵素
    PTGS1 (COX1)
     D00126  イブプロフェン (JP17) <JP/US>
    PTGS2 (COX2)
     D00126  イブプロフェン (JP17) <JP/US>
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00126  イブプロフェン
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00126
日本のスイッチOTC薬 [jp08314.html]
 医療用から一般用へのスイッチOTC薬
  D00126
リンク   
CAS: 15687-27-1
PubChem: 7847194
ChEBI: 5855
ChEMBL: CHEMBL521
DrugBank: DB01050
LigandBox: D00126
日化辞: J3.134H
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