KEGG   DRUG: カルベジロール
エントリ  
D00255                      Drug                                   

一般名   
カルベジロール (JP17);
Carvedilol (JP17/USP/INN)
商品名   
  後発品
米国の商品 
  後発品
CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (A-S Medication Solutions), CARVEDILOL (ACETRIS HEALTH), CARVEDILOL (American Health Packaging), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aphena Pharma Solutions - Tennessee), CARVEDILOL (Aurobindo Pharma Limited), CARVEDILOL (Bayshore Pharmaceuticals LLC), CARVEDILOL (BluePoint Laboratories), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Bryant Ranch Prepack), CARVEDILOL (Cadila Healthcare Limited), CARVEDILOL (Cardinal Health), CARVEDILOL (Cardinal Health), CARVEDILOL (Clinical Solutions Wholesale), CARVEDILOL (DIRECT RX), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Denton Pharma), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Direct_Rx), CARVEDILOL (Dr. Reddy's Laboratories Limited), CARVEDILOL (Glenmark Pharmaceuticals), CARVEDILOL (Golden State Medical Supply), CARVEDILOL (Lake Erie Medical DBA Quality Care Products LLC), CARVEDILOL (Legacy Pharmaceutical Packaging), CARVEDILOL (Major Pharmaceuticals), CARVEDILOL (Marlex Pharmaceuticals), CARVEDILOL (Mylan Institutional), CARVEDILOL (Mylan Pharmaceuticals), CARVEDILOL (NCS HealthCare of KY), CARVEDILOL (Northwind Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (NuCare Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (PD-Rx Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Preferred Pharmaceuticals), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (Proficient Rx LP), CARVEDILOL (QPharma), CARVEDILOL (Quality Care Products), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (REMEDYREPACK), CARVEDILOL (Sandoz), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (St. Mary's Medical Park Pharmacy), CARVEDILOL (Teva Pharmaceuticals USA), CARVEDILOL (Unit Dose Services), CARVEDILOL (Zydus Pharmaceuticals (USA))
組成式   
C24H26N2O4
質量    
406.1893
分子量   
406.4742
構造式   
Simcomp   
クラス   
循環器系用薬
 DG01466  アドレナリン受容体拮抗薬
  DG01464  β-アドレナリン受容体拮抗薬
   DG01461  β1-アドレナリン受容体拮抗薬
   DG01462  β2-アドレナリン受容体拮抗薬
   DG01463  β3-アドレナリン受容体拮抗薬
  DG01465  α-アドレナリン受容体拮抗薬
   DG01457  α1-アドレナリン受容体拮抗薬
代謝酵素基質薬
 DG01892  CYP1A2基質薬
 DG01642  CYP2C9基質薬
 DG01644  CYP2D6基質薬
 DG02855  CYP2E1基質薬
 DG02913  CYP3A4基質薬
トランスポーター阻害薬
 DG01622  ABCB1(P糖蛋白質)阻害薬
コード   
同一コード: C06875
薬効分類: 2149
ATCコード: C07AG02
化学構造グループ: DG00321
商品 (DG00321): D00255<JP/US> D03415<US>
効能    
血圧降下薬, α1β遮断薬
  疾患
本態性高血圧症 [DS:H01633]
狭心症 [DS:H01632]
拡張型心筋症 [DS:H00294]
頻脈性心房細動 [DS:H00731]
ターゲット 
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
  パスウェイ
hsa04020  カルシウムシグナル伝達経路
hsa04022  cGMP-PKG シグナル伝達経路
hsa04024  cAMP シグナル伝達経路
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04261  心筋細胞におけるアドレナリンシグナル伝達
hsa04270  血管平滑筋の収縮
hsa05414  拡張型心筋症
代謝    
Enzyme: CYP2D6 [HSA:1565], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2E1 [HSA:1571]
相互作用  
Transporter inhibition: ABCB1 [HSA:5243]

構造マップ 
map07215  α-アドレナリン受容体の作動薬と拮抗薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   214  血圧降下剤
    2149  その他の血圧降下剤
     D00255  カルベジロール (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C07 ベータ遮断薬
   C07A ベータ遮断薬
    C07AG アルファ及びベータ遮断薬
     C07AG02 カルベジロール
      D00255  カルベジロール (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  ベータアドレナリン遮断薬
   ベータアドレナリン遮断薬, その他
    カルベジロール
     D00255  カルベジロール (JP17)
ターゲットに基づく医薬品分類 [BR:jp08310]
 Gタンパク質共役受容体
  ロドプシンファミリー
   アドレナリン
    ADRA1
     D00255  カルベジロール (JP17) <JP/US>
    ADRB1
     D00255  カルベジロール (JP17) <JP/US>
    ADRB2
     D00255  カルベジロール (JP17) <JP/US>
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00255  カルベジロール
  D00255  カルベジロール錠
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00255
 薬物トランスポーター
  D00255
ゲノムバイオマーカー [jp08341.html]
 医薬品応答に影響を与える多型と変異
  D00255
リンク   
CAS: 72956-09-3
PubChem: 7847321
ChEBI: 3441
ChEMBL: CHEMBL723
DrugBank: DB01136
LigandBox: D00255
日化辞: J33.955E
LinkDB    

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