KEGG   DRUG: ジルチアゼム塩酸塩
エントリ  
D00616                      Drug                                   

一般名   
ジルチアゼム塩酸塩 (JP17);
Diltiazem hydrochloride (JP17/USP)
商品名   
  後発品
米国の商品 
  後発品
DILTIAZEM HCI (HF Acquisition Co LLC), DILTIAZEM HCI (HF Acquisition Co LLC), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), CARTIA (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (A-S Medication Solutions), DILTIAZEM HYDROCHLORIDE (Accord Healthcare), DILTIAZEM HYDROCHLORIDE (Actavis Pharma), CARTIA (Actavis Pharma), TAZTIA (Actavis Pharma), MATZIM LA (Actavis Pharma), DILTIAZEM HYDROCHLORIDE (Akorn), DILTIAZEM HYDROCHLORIDE (Akorn), DILTIAZEM HYDROCHLORIDE (American Health Packaging), DILTIAZEM HYDROCHLORIDE (American Health Packaging), DILTIAZEM HYDROCHLORIDE (Apotex Corp.), DILTIAZEM HYDROCHLORIDE (Athenex Pharmaceutical Division), DILTIAZEM HYDROCHLORIDE (AvKARE), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), CARTIA (Bryant Ranch Prepack), CARTIA (Bryant Ranch Prepack), DILTIAZEM HYDROCHLORIDE (Bryant Ranch Prepack), TIADYLT ER (Cadila Healthcare Limited), DILTIAZEM HYDROCHLORIDE (Cadila Healthcare Limited), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Cardinal Health), DILTIAZEM HYDROCHLORIDE (Clinical Solutions Wholesale), DILTIAZEM HYDROCHLORIDE (Denton Pharma), DILTIAZEM HYDROCHLORIDE (Denton Pharma), DILTIAZEM HYDROCHLORIDE (Denton Pharma), DILTIAZEM HYDROCHLORIDE (Denton Pharma), DILTIAZEM HYDROCHLORIDE (Denton Pharma), DILTIAZEM HYDROCHLORIDE (Edenbridge Pharmaceuticals LLC.), DILTIAZEM HYDROCHLORIDE (Hospira), DILTIAZEM HYDROCHLORIDE (Ingenus Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), DILTIAZEM HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), DILTIAZEM HYDROCHLORIDE (Medical Purchasing Solutions), DILTIAZEM HYDROCHLORIDE (Mylan Institutional), DILTIAZEM HYDROCHLORIDE (Mylan Institutional), DILTIAZEM HYDROCHLORIDE (Mylan Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NCS HealthCare of KY), DILTIAZEM HYDROCHLORIDE (NCS HealthCare of KY), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceutical), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceutical), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (NuCare Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (OCEANSIDE PHARMACEUTICALS), DILTIAZEM HYDROCHLORIDE (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Par Pharmaceutical), DILTIAZEM HYDROCHLORIDE (Preferred Pharmaceutials), DILTIAZEM HYDROCHLORIDE (Preferred Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Preferred Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Proficient Rx LP), DILTIAZEM HYDROCHLORIDE (PuraCap Laboratories LLC), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), MATZIM LA (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), CARTIA (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK), DILTIAZEM HYDROCHLORIDE (Sun Pharmaceutical Industries), DILTIAZEM HYDROCHLORIDE (Sun Pharmaceutical Industries), DILTIAZEM HYDROCHLORIDE (Sun Pharmaceutical Industries), DILTIAZEM HYDROCHLORIDE (TWi Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (Teva Pharmaceuticals USA), DILTIAZEM HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), DILTIAZEM HYDROCHLORIDE (West-Ward Pharmaceuticals Corp.), TIADYLT ER (Zydus Pharmaceuticals (USA)), DILTIAZEM HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), DILTIAZEM HYDROCHLORIDE (Oceanside Pharmaceuticals), DILTIAZEM HYDROCHLORIDE (REMEDYREPACK)
組成式   
C22H26N2O4S. HCl
質量    
450.138
分子量   
450.9788
構造式   
Simcomp   
クラス   
循環器系用薬
 DG01653  抗不整脈薬
その他
 DG01575  カルシウムチャネル遮断薬
  DG01496  カルシウムチャネルL型遮断薬
代謝酵素基質薬
 DG02913  CYP3A4基質薬
コード   
薬効分類: 2171
ATCコード: C05AE03 C08DB01
化学構造グループ: DG00331
商品 (DG00331): D00616<JP/US>
効能    
抗不整脈薬, 血圧降下薬, 冠血管拡張薬, カルシウムチャネル遮断薬
  疾患
狭心症 [DS:H01632]
本態性高血圧症 [DS:H01633]
コメント  
ベンゾジアゼピン誘導体
ターゲット 
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  パスウェイ
hsa04024  cAMP シグナル伝達経路
hsa04260  心筋の収縮
hsa04261  心筋細胞におけるアドレナリンシグナル伝達
hsa04270  血管平滑筋の収縮
代謝    
Enzyme: CYP3A4 [HSA:1576]
相互作用  

構造マップ 
map07036  カルシウムチャネル遮断薬
map07037  抗不整脈薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   217  血管拡張剤
    2171  冠血管拡張剤
     D00616  ジルチアゼム塩酸塩 (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C05 血管保護薬
   C05A 痔核と裂肛の局所用治療薬
    C05AE 筋弛緩薬
     C05AE03 ジルチアゼム
      D00616  ジルチアゼム塩酸塩 (JP17) <JP/US>
  C08 カルシウムチャネル遮断薬
   C08D 選択的カルシウムチャネル遮断薬、直接に心臓への効果がある
    C08DB ベンゾチアゼピン誘導体
     C08DB01 ジルチアゼム
      D00616  ジルチアゼム塩酸塩 (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  抗不整脈薬
   Vaughn WilliamsクラスIV
    ジルチアゼム
     D00616  ジルチアゼム塩酸塩 (JP17)
  カルシウムチャネル遮断薬, 非ジヒドロピリジン
   ジルチアゼム
    D00616  ジルチアゼム塩酸塩 (JP17)
ターゲットに基づく医薬品分類 [BR:jp08310]
 イオンチャネル
  電位依存性イオンチャネル
   カルシウムチャネル
    CACNA1-L
     D00616  ジルチアゼム塩酸塩 (JP17) <JP/US>
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00616  ジルチアゼム塩酸塩
  D00616  ジルチアゼム塩酸塩徐放カプセル
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00616
リンク   
CAS: 33286-22-5
PubChem: 7847682
ChEBI: 645509
ChEMBL: CHEMBL1697
DrugBank: DB00343
LigandBox: D00616
日化辞: J253.795H
LinkDB    

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