KEGG   DRUG: トラゾドン塩酸塩Help
エントリ  
D00820                      Drug                                   

一般名   
トラゾドン塩酸塩 (JAN);
Trazodone hydrochloride (JAN/USP)
商品名   
  後発品
米国の商品 
  後発品
TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (A-S Medication Solutions), TRAZODONE HYDROCHLORIDE (Accord Healthcare), TRAZODONE HYDROCHLORIDE (American Health Packaging), TRAZODONE HYDROCHLORIDE (American Health Packaging), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAZODONE HYDROCHLORIDE (Apotex Corp), TRAZODONE HYDROCHLORIDE (AvKARE), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Bryant Ranch Prepack), TRAZODONE HYDROCHLORIDE (Cadila Healthcare Limited), TRAZODONE HYDROCHLORIDE (Cardinal Health), TRAZODONE HYDROCHLORIDE (Cardinal Health), TRAZODONE HYDROCHLORIDE (Clinical Solutions Wholesale), TRAZODONE HYDROCHLORIDE (DIRECT RX), TRAZODONE HYDROCHLORIDE (Denton Pharma), TRAZODONE HYDROCHLORIDE (Denton Pharma), TRAZODONE HYDROCHLORIDE (Denton Pharma), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Direct_Rx), TRAZODONE HYDROCHLORIDE (Golden State Medical Supply), TRAZODONE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), TRAZODONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAZODONE HYDROCHLORIDE (Major Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Major Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Medsource Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NCS HealthCare of KY), TRAZODONE HYDROCHLORIDE (NCS HealthCare of KY), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmaceuticals), TRAZODONE HYDROCHLORIDE (NuCare Pharmceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Par Pharmaceutical), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Preferred Pharmaceuticals), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Proficient Rx LP), TRAZODONE HYDROCHLORIDE (Quality Care Products), TRAZODONE HYDROCHLORIDE (Quality Care Products), TRAZODONE HYDROCHLORIDE (Quality Care Products), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (REMEDYREPACK), TRAZODONE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), TRAZODONE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), TRAZODONE HYDROCHLORIDE (Sun Pharmaceutical Industries), TRAZODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAZODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAZODONE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), TRAZODONE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
組成式   
C19H22ClN5O. HCl
質量    
407.128
分子量   
408.3248
構造式   
Mol fileKCF fileDB search
Simcomp    SIMCOMP
クラス   
代謝酵素基質薬
 DG01644  CYP2D6基質薬
 DG02913  CYP3A4基質薬
コード   
薬効分類: 1179
ATCコード: N06AX05
化学構造グループ: DG00952
商品 (DG00952): D00820<JP/US>
効能    
抗うつ薬, セロトニン受容体拮抗・再取り込み阻害薬
  疾患
うつ病・うつ状態 [DS:H01646]
コメント  
トリアゾロピリジン誘導体
ターゲット 
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  パスウェイ
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04726  セロトニン作動性シナプス
代謝    
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
相互作用  
Drug interaction
構造マップ 
map07027  抗うつ薬
map07234  神経伝達物質トランスポーター阻害薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   117  精神神経用剤
    1179  その他の精神神経用剤
     D00820  トラゾドン塩酸塩 (JAN)
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N06 精神賦活薬
   N06A 抗うつ薬
    N06AX その他の抗うつ薬
     N06AX05 トラゾドン
      D00820  トラゾドン塩酸塩 (JAN) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 抗うつ薬
  SSRIs/SNRIs(選択的セロトニン/ノルアドレナリン再取り込み阻害薬)
   トラゾドン
    D00820  トラゾドン塩酸塩 (JAN)
ターゲットに基づく医薬品分類 [BR:jp08310]
 Gタンパク質共役受容体
  ロドプシンファミリー
   セロトニン
    HTR2
     D00820  トラゾドン塩酸塩 (JAN) <JP/US>
 トランスポーター
  SLC ファミリー
   SLC6
    SLC6A4 (HTT)
     D00820  トラゾドン塩酸塩 (JAN) <JP/US>
BRITE hierarchy
リンク   
CAS: 25332-39-2
PubChem: 7847885
ChEBI: 9655
ChEMBL: CHEMBL1200798
DrugBank: DB00656
LigandBox: D00820
日化辞: J262.568G
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