KEGG   DISEASE: Testicular cancerHelp
Entry
H00023                      Disease                                

Name
Testicular cancer
Description
Testicular germ cell tumor (TGCT) comprises about 98% of all testicular neoplasms and is thereby the most common malignancy among young males. Overall, three different entities of TGCT can be distinguished: teratomas and yolk sac tumors of newborns and infants, seminomatous and nonseminomatous germ cell tumors of adolescents and young adults, and spermatocytic seminoma of elderly men. Recent studies of TGCTs have suggested that overexpression of cyclin D2 is a very early, possibly the oncogenic, event in GC tumorigenesis.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of male genital organs
   H00023  Testicular cancer
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of male genital organs
     2C80  Malignant neoplasms of testis
      H00023  Testicular cancer
Tumor markers [br08442.html]
 H00023
Cancer-accociated carbohydrates [br08441.html]
 H00023
BRITE hierarchy
Gene
Cyclin D2 (amplification) [HSA:894] [KO:K10151]
Drug
Ifosfamide [DR:D00343]
Vinblastine sulfate [DR:D01068]
Etoposide [DR:D00125]
Etoposide phosphate [DR:D04107]
Dactinomycin [DR:D00214]
Bleomycin sulfate [DR:D02177]
Cisplatin [DR:D00275]
Comment
ICD-O: 9064/2, Tumor type: Intratubular germ cell neoplasia, unclassified
ICD-O: 9061/3, Tumor type: Seminoma
ICD-O: 9063/3, Tumor type: Spermatocytic seminoma
ICD-O: 9100/3, Tumor type: Choriocarcinoma
ICD-O: 9070/3, Tumor type: Embryonal carcinooma
ICD-O: 9071/3, Tumor type: Yolk sac tumor
ICD-O: 9080/3, Tumor type: Teratoma
Other DBs
ICD-11: 2C80
ICD-10: C62
MeSH: D013736
Reference
PMID:18042148 (description, tumor type)
  Authors
Lind GE, Skotheim RI, Lothe RA
  Title
The epigenome of testicular germ cell tumors.
  Journal
APMIS 115:1147-60 (2007)
DOI:10.1111/j.1600-0463.2007.apm_660.xml.x
Reference
PMID:10749107 (gene, tumor type)
  Authors
Chaganti RS, Houldsworth J.
  Title
Genetics and biology of adult human male germ cell tumors.
  Journal
Cancer Res 60:1475-82 (2000)
Reference
PMID:9791864 (gene, tumor type)
  Authors
Lutzker SG, Barnard NJ.
  Title
Testicular germ cell tumors: molecular understanding and clinical implications.
  Journal
Mol Med Today 4:404-11 (1998)
DOI:10.1016/S1357-4310(98)01329-X
Reference
PMID:16095047 (tumor type)
  Authors
Stenman UH.
  Title
Testicular cancer: the perfect paradigm for marker combinations.
  Journal
Scand J Clin Lab Invest 65:181-8 (2005)
DOI:10.1080/00365510510013820
Reference
PMID:9820318 (tumor type)
  Authors
Horwich A, Huddart R, Dearnaley D.
  Title
Markers and management of germ-cell tumours of the testes.
  Journal
Lancet 352:1535-8 (1998)
DOI:10.1016/S0140-6736(98)04251-2
Reference
PMID:17683189 (tumor type)
  Authors
Bahrami A, Ro JY, Ayala AG.
  Title
An overview of testicular germ cell tumors.
  Journal
Arch Pathol Lab Med 131:1267-80 (2007)
DOI:10.1043/1543-2165(2007)131[1267:AOOTGC]2.0.CO;2
Reference
PMID:17414640 (tumor type)
  Authors
Bridges B, Hussain A.
  Title
Testicular germ cell tumors.
  Journal
Curr Opin Oncol 19:222-8 (2007)
DOI:10.1097/CCO.0b013e3280ad43df
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