Entry |
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Name |
Basal cell carcinoma |
Description |
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
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Category |
Cancer
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Brite |
Human diseases [BR:br08402]
Cancers
Skin cancers
H00039 Basal cell carcinoma
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms of skin
2C32 Basal cell carcinoma of skin
H00039 Basal cell carcinoma
Cancer-associated carbohydrates [br08441.html]
H00039
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Pathway |
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Network |
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Element |
N00010 | Mutation-inactivated PTCH1 to Hedgehog signaling pathway |
N00017 | Mutation-activated SMO to Hedgehog signaling pathway |
N00115 | Mutation-inactivated TP53 to transcription |
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Gene |
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Carcinogen |
Arsenic in drinking-water
Solar radiation
*Benzo[a]pyrene [CPD: C07535]
*Chimney sweeping
*Mineral oils, untreated and mildly treated
*: Although this is a risk factor for skin cancer in general, the strength of association with different histological tumor types is not well understood.
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Drug |
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Comment |
ICD-O: 8090/3, Tumor type: Basal cell carcinoma
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Other DBs |
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Reference |
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Authors |
Daya-Grosjean L, Couve-Privat S. |
Title |
Sonic hedgehog signaling in basal cell carcinomas. |
Journal |
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Reference |
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Authors |
Khavari PA. |
Title |
Modelling cancer in human skin tissue. |
Journal |
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Reference |
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Authors |
Tsai KY, Tsao H. |
Title |
The genetics of skin cancer. |
Journal |
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Reference |
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Authors |
Rossman TG. |
Title |
Mechanism of arsenic carcinogenesis: an integrated approach. |
Journal |
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Reference |
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Authors |
Walvekar RR, Kane SV, Nadkarni MS, Bagwan IN, Chaukar DA, D'Cruz AK. |
Title |
Chronic arsenic poisoning: a global health issue -- a report of multiple primary cancers. |
Journal |
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Reference |
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Authors |
Hussein MR. |
Title |
Ultraviolet radiation and skin cancer: molecular mechanisms. |
Journal |
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Reference |
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Authors |
Luch A. |
Title |
Nature and nurture - lessons from chemical carcinogenesis. |
Journal |
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Reference |
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Authors |
Abnet CC. |
Title |
Carcinogenic food contaminants. |
Journal |
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Reference |
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Authors |
Boffetta P, Jourenkova N, Gustavsson P. |
Title |
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. |
Journal |
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Reference |
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Authors |
Tolbert PE. |
Title |
Oils and cancer. |
Journal |
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Reference |
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Authors |
Takeuchi Y, Tamura A, Kamiya M, Fukuda T, Ishikawa O. |
Title |
Immunohistochemical analyses of p63 expression in cutaneous tumours. |
Journal |
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Reference |
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Authors |
Park HR, Min SK, Cho HD, Kim KH, Shin HS, Park YE. |
Title |
Expression profiles of p63, p53, survivin, and hTERT in skin tumors. |
Journal |
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LinkDB |
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