Gallbladder cancer

Gallbladder cancer (GBC) is a relatively uncommon neoplasm, however its prognosis is poor with less than a 5% 5-year survival rate. There are considerable geographic differences in its incidence and etiology. Two main pathways of GBC pathogenesis have been identified. The most common is associated with gallstones and chronic inflammation of the gallbladder, whereas a second, less frequent pathway is associated with a congenital abnormality of the pancreatic bile-duct junction, which is particularly common in Japan. TP53 inactivation has an important and early role in GBC associated with gallstones and chronic inflammation. Although KRAS mutations are rarely detected in GBC associated with gallstones, they are frequent and early events in tumors associated with congenital abnormality of the pancreatic bile-duct junction.

Cancer

p53 (mutation) [HSA:7157] [KO:K04451]
p16/INK4A (mutation) [HSA:1029] [KO:K06621]
K-ras (mutation) [HSA:3845] [KO:K07827]
APC (mutation) [HSA:324] [KO:K02085]

ICD-O: 8140/3, Tumor type: Adenocarcinoma

PMID:15343276 (description, gene, tumor type)

Wistuba II, Gazdar AF.

Gallbladder cancer: lessons from a rare tumour.

Nat Rev Cancer 4:695-706 (2004)
DOI:10.1038/nrc1429

Hansel DE, Argani P.

Pathology of the gallbladder: a concise review.

Current Diagnostic Pathology 10:304-317 (2004)
DOI:10.1016/j.cdip.2004.03.006

PMID:10526058

Wistuba II, Albores-Saavedra J.

Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.

J Hepatobiliary Pancreat Surg 6:237-44 (1999)
DOI:10.1007/s005340050113

PMID:11410326

Kim YT, Kim J, Jang YH, Lee WJ, Ryu JK, Park YK, Kim SW, Kim WH, Yoon YB, Kim CY.

Genetic alterations in gallbladder adenoma, dysplasia and carcinoma.

Cancer Lett 169:59-68 (2001)
DOI:10.1016/S0304-3835(01)00562-6