Entry |
|
Name |
Gallbladder cancer |
Description |
Gallbladder cancer (GBC) is a relatively uncommon neoplasm, however its prognosis is poor with less than a 5% 5-year survival rate. There are considerable geographic differences in its incidence and etiology. Two main pathways of GBC pathogenesis have been identified. The most common is associated with gallstones and chronic inflammation of the gallbladder, whereas a second, less frequent pathway is associated with a congenital abnormality of the pancreatic bile-duct junction, which is particularly common in Japan. TP53 inactivation has an important and early role in GBC associated with gallstones and chronic inflammation. Although KRAS mutations are rarely detected in GBC associated with gallstones, they are frequent and early events in tumors associated with congenital abnormality of the pancreatic bile-duct junction.
|
Category |
Cancer
|
Brite |
Human diseases [BR:br08402]
Cancers
Cancers of the digestive system
H00047 Gallbladder cancer
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms of digestive organs
2C13 Malignant neoplasms of gallbladder
H00047 Gallbladder cancer
Tumor markers [br08442.html]
H00047
|
Gene |
|
Comment |
ICD-O: 8140/3, Tumor type: Adenocarcinoma
|
Other DBs |
|
Reference |
PMID: 15343276 (description, gene, tumor type) |
Authors |
Wistuba II, Gazdar AF. |
Title |
Gallbladder cancer: lessons from a rare tumour. |
Journal |
|
Reference |
|
Authors |
Hansel DE, Argani P. |
Title |
Pathology of the gallbladder: a concise review. |
Journal |
|
Reference |
|
Authors |
Wistuba II, Albores-Saavedra J. |
Title |
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma. |
Journal |
|
Reference |
|
Authors |
Kim YT, Kim J, Jang YH, Lee WJ, Ryu JK, Park YK, Kim SW, Kim WH, Yoon YB, Kim CY. |
Title |
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. |
Journal |
|
LinkDB |
|