KEGG   DISEASE: Gallbladder cancerHelp
Entry
H00047                      Disease                                

Name
Gallbladder cancer
Description
Gallbladder cancer (GBC) is a relatively uncommon neoplasm, however its prognosis is poor with less than a 5% 5-year survival rate. There are considerable geographic differences in its incidence and etiology. Two main pathways of GBC pathogenesis have been identified. The most common is associated with gallstones and chronic inflammation of the gallbladder, whereas a second, less frequent pathway is associated with a congenital abnormality of the pancreatic bile-duct junction, which is particularly common in Japan. TP53 inactivation has an important and early role in GBC associated with gallstones and chronic inflammation. Although KRAS mutations are rarely detected in GBC associated with gallstones, they are frequent and early events in tumors associated with congenital abnormality of the pancreatic bile-duct junction.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of the digestive system
   H00047  Gallbladder cancer
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of digestive organs
     2C13  Malignant neoplasms of gallbladder
      H00047  Gallbladder cancer
Tumor markers [br08442.html]
 H00047
BRITE hierarchy
Gene
p53 (mutation) [HSA:7157] [KO:K04451]
p16/INK4A (mutation) [HSA:1029] [KO:K06621]
K-ras (mutation) [HSA:3845] [KO:K07827]
APC (mutation) [HSA:324] [KO:K02085]
Comment
ICD-O: 8140/3, Tumor type: Adenocarcinoma
Other DBs
ICD-11: 2C13
ICD-10: C23
MeSH: D005706
Reference
PMID:15343276 (description, gene, tumor type)
  Authors
Wistuba II, Gazdar AF.
  Title
Gallbladder cancer: lessons from a rare tumour.
  Journal
Nat Rev Cancer 4:695-706 (2004)
DOI:10.1038/nrc1429
Reference
  Authors
Hansel DE, Argani P.
  Title
Pathology of the gallbladder: a concise review.
  Journal
Current Diagnostic Pathology 10:304-317 (2004)
DOI:10.1016/j.cdip.2004.03.006
Reference
  Authors
Wistuba II, Albores-Saavedra J.
  Title
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
  Journal
J Hepatobiliary Pancreat Surg 6:237-44 (1999)
DOI:10.1007/s005340050113
Reference
  Authors
Kim YT, Kim J, Jang YH, Lee WJ, Ryu JK, Park YK, Kim SW, Kim WH, Yoon YB, Kim CY.
  Title
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma.
  Journal
Cancer Lett 169:59-68 (2001)
DOI:10.1016/S0304-3835(01)00562-6
LinkDB All DBs

» Japanese version

DBGET integrated database retrieval system