KEGG   DISEASE: Enteropathogenic Escherichia coli (EPEC) infectionHelp
Entry
H00278                      Disease                                

Name
Enteropathogenic Escherichia coli (EPEC) infection
Description
Enteropathogenic Escherichia coli (EPEC) was the first pathotype of E. coli identified in the 1940s, and remains a common cause of infantile diarrhea in developing countries. EPEC and EHEC [DS:H00277] strains are characterized by the type III secretion system and its cognate effectors encoded in the locus of enterocyte effacement (LEE), but EPEC does not release diffusible toxins.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00278  Enteropathogenic Escherichia coli (EPEC) infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial intestinal infections
    1A03  Intestinal infections due to Escherichia coli
     H00278  Enteropathogenic Escherichia coli (EPEC) infection
BRITE hierarchy
Pathway
hsa05130  Pathogenic Escherichia coli infection
Network
  Element
N00926  Escherichia Tir to TLR2/4-MAPK signaling pathway
N00927  Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway
N00928  Escherichia NleB to TNF-NFKB signaling pathway
N00929  Escherichia NleC to TNF-NFKB signaling pathway
N00930  Escherichia NleD to TNF-JNK signaling pathway
N00931  Escherichia NleD to TNF-p38 signaling pathway
N00932  Escherichia NleH1 to TNF-NFKB signaling pathway
N00933  Escherichia NleA to NLRP3 inflammasome signaling pathway
N00935  Escherichia NleF to non-canonical inflammasome signaling pathway
N00936  Escherichia NleB1 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00937  Escherichia NleF to extrinsic apoptotic pathway
N00938  Escherichia NleH to intrinsic apoptotic pathway
N00939  Escherichia NleF to intrinsic apoptotic pathway
Pathogen
Escherichia coli O127:H6 [GN:ecg]
Escherichia coli O55:H7 [GN:eok elr]
  Module
M00542  EHEC/EPEC pathogenicity signature, T3SS and effectors
Other DBs
ICD-11: 1A03.0
ICD-10: A04.0
MeSH: D004927
Reference
  Authors
Ochoa TJ, Barletta F, Contreras C, Mercado E
  Title
New insights into the epidemiology of enteropathogenic Escherichia coli infection.
  Journal
Trans R Soc Trop Med Hyg 102:852-6 (2008)
DOI:10.1016/j.trstmh.2008.03.017
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