KEGG   DISEASE: PlagueHelp
Entry
H00297                      Disease                                

Name
Plague
Description
Plague is a deadly infectious disease caused by Yersinia pestis. The pathogen has rodent reservoirs and is transmitted to humans usually by fleas as vectors. There are three major manifestations: bubonic, septicemic, and pneumonic plagues. Severe epidemics in the past include the Plague of Justinian in the sixth century, the Black Death in the fourteenth century, and the Third Pandemic that began in Central Asia in the nineteenth century. The genome sequences have been determined for the strains responsible for these epidemics.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00297  Plague
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Certain zoonotic bacterial diseases
   1B93  Plague
    H00297  Plague
BRITE hierarchy
Network
  Element
N00859  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00860  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00861  Yersinia YopP/J to TLR2/4-NFKB signaling pathway
N00862  Yersinia YopP/J to TLR2/4-MAPK signaling pathway
N00863  Yersinia YopM to NLRP3 Inflammasome signaling pathway
N00864  Yersinia YopK to NLRP3 Inflammasome signaling pathway
N00865  Yersinia YopK to NLRC4 Inflammasome signaling pathway
N00866  Yersinia YopM to Pyrin Inflammasome signaling pathway
Pathogen
Yersinia pestis CO92 (biovar Orientalis) [GN:ype] (Third Pandemic)
Yersinia pestis KIM (biovar Mediaevalis) [GN:ypk] (Black Death)
Yersinia pestis Antiqua,Nepal516 (biovar Antiqua) [GN:ypa ypn] (Plague of Justinian)
Yersinia pestis Pestoides F [GN:ypp]
Yersinia pestis Angola [GN:ypg]
Yersinia pestis D106004 [GN:ypd]
Yersinia pestis D182038 [GN:ypx]
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline hyclate [DR:D02129]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Streptomycin sulfate [DR:D01350]
Demeclocycline hydrochloride [DR:D00290]
Ciprofloxacin [DR:D00186]
Ciprofloxacin hydrochloride [DR:D02216]
Levofloxacin [DR:D00588]
Moxifloxacin hydrochloride [DR:D00874]
Comment
Vector: Xenopsylla cheopis (rat flea)
murine toxin [KO:K11009]
Other DBs
ICD-11: 1B93
ICD-10: A20
MeSH: D010930
MedlinePlus: 000596
LinkDB All DBs

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