| Entry |
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| Name |
Shigellosis;
Bacillary dysentery |
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| Description |
Shigellosis (bacillary dysentery) is a foodborne enterobacterial infection caused by Shigella species. There are four subgroups of Shigella: S. dysenteriae, S. flexneri, S. boydii, and S. sonnei. Of these, S. flexneri is the most frequently observed worldwide, and S. dysenteriae causes severe disease with the highest fatality rate. Clinical symptoms include an acute rectocolitis associated with fever, nausea, anorexia, dehydration, mucopurulent and bloody diarrhea, and tenesmus. Transmission usually occurs via contaminated food and water or through person-to-person contact. In humans, shigellosis can be provoked by an extremely small number of organisms (10-100).
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| Category |
Infectious disease
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| Brite |
Infectious diseases [BR:br08401]
Bacterial infections
Infections caused by enterobacteria
H00299 Shigellosis
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
Gastroenteritis or colitis of infectious origin
Bacterial intestinal infections
1A02 Intestinal infections due to Shigella
H00299 Shigellosis
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| Pathway |
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| Network |
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| Element |
| N00927 | Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway |
| N00941 | Shigella IpaH9.8 to NOD-NFKB signaling pathway |
| N00942 | Shigella OspG to TNF-NFKB signaling pathway |
| N00943 | Shigella IpaH4.5 to TNF-NFKB signaling pathway |
| N00944 | Shigella OspI to TNF-NFKB signaling pathway |
| N00945 | Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway |
| N00946 | Shigella IpaJ to cGAS-STING signaling pathway |
| N00947 | Shigella Ipa4.5 to cGAS-STING signaling pathway |
| N00948 | Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway |
| N00949 | Shigella IpaB to NLRC4 Inflammasome signaling pathway |
| N00950 | Escherichia/Salmonella/Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways |
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| Pathogen |
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| Drug |
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| Other DBs |
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| Reference |
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| Authors |
Kweon MN |
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| Title |
Shigellosis: the current status of vaccine development. |
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| Journal |
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| Reference |
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| Authors |
Warren BR, Parish ME, Schneider KR |
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| Title |
Shigella as a foodborne pathogen and current methods for detection in food. |
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| Journal |
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| Reference |
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| Authors |
Niyogi SK |
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| Title |
Shigellosis. |
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| Journal |
J Microbiol 43:133-43 (2005) |
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| LinkDB |
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