KEGG   DISEASE: ShigellosisHelp
Entry
H00299                      Disease                                

Name
Shigellosis;
Bacillary dysentery
Description
Shigellosis (bacillary dysentery) is a foodborne enterobacterial infection caused by Shigella species. There are four subgroups of Shigella: S. dysenteriae, S. flexneri, S. boydii, and S. sonnei. Of these, S. flexneri is the most frequently observed worldwide, and S. dysenteriae causes severe disease with the highest fatality rate. Clinical symptoms include an acute rectocolitis associated with fever, nausea, anorexia, dehydration, mucopurulent and bloody diarrhea, and tenesmus. Transmission usually occurs via contaminated food and water or through person-to-person contact. In humans, shigellosis can be provoked by an extremely small number of organisms (10-100).
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by enterobacteria
   H00299  Shigellosis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial intestinal infections
    1A02  Intestinal infections due to Shigella
     H00299  Shigellosis
BRITE hierarchy
Pathway
hsa05131  Shigellosis
Network
  Element
N00927  Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway
N00941  Shigella IpaH9.8 to NOD-NFKB signaling pathway
N00942  Shigella OspG to TNF-NFKB signaling pathway
N00943  Shigella IpaH4.5 to TNF-NFKB signaling pathway
N00944  Shigella OspI to TNF-NFKB signaling pathway
N00945  Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway
N00946  Shigella IpaJ to cGAS-STING signaling pathway
N00947  Shigella Ipa4.5 to cGAS-STING signaling pathway
N00948  Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
N00949  Shigella IpaB to NLRC4 Inflammasome signaling pathway
N00950  Escherichia/Salmonella/Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways
Pathogen
Shigella flexneri [GN:sfl sfx sfv sfe sft]
Shigella sonnei [GN:ssn]
Shigella boydii [GN:sbo sbc]
Shigella dysenteriae [GN:sdy sdz]
shiga toxin [KO:K11006 K11007]
enterotoxin ShET-1 [KO:K11011 K11012]
Drug
Co-Trimoxazole [DR:D00285]
Other DBs
ICD-11: 1A02
ICD-10: A03
MeSH: D004405
MedlinePlus: 000295
Reference
  Authors
Kweon MN
  Title
Shigellosis: the current status of vaccine development.
  Journal
Curr Opin Infect Dis 21:313-8 (2008)
DOI:10.1097/QCO.0b013e3282f88b92
Reference
  Authors
Warren BR, Parish ME, Schneider KR
  Title
Shigella as a foodborne pathogen and current methods for detection in food.
  Journal
Crit Rev Food Sci Nutr 46:551-67 (2006)
DOI:10.1080/10408390500295458
Reference
  Authors
Niyogi SK
  Title
Shigellosis.
  Journal
J Microbiol 43:133-43 (2005)
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