KEGG   DISEASE: Helicobacter pylori infection
Entry
H00320                      Disease                                

Name
Helicobacter pylori infection
Description
Helicobacter pylori (HP) is a gram-negative pathogenic bacterium that specifically colonizes in the gastric epithelium and causes chronic gastritis, peptic ulcer disease, and/or gastric malignancies. Persistent infection can cause inflammation and gastritis that may lead to carcinogenesis. Transmission is still not entirely clarified, but human-to-human spread through oral-oral or fecal-oral route is thought to be the most plausible. The prevalence of HP infection varies between different geographical regions; generally, the prevalence is about 30% in developed and up to 80% in developing countries. Although HP may sometimes be eradicated by antibiotics given for other infections, infection usually persists life-long unless specific combination antibiotic therapy is taken.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by epsilon proteobacteria
   H00320  Helicobacter pylori infection
Pathway
hsa05120  Epithelial cell signaling in Helicobacter pylori infection
Pathogen
  Module
M00564  Helicobacter pylori pathogenicity signature, cagA pathogenicity island
Drug
Omeprazole magnesium [DR:D05259]
Lansoprazole [DR:D00355]
Rabeprazole sodium [DR:D00724]
Esomeprazole magnesium [DR:D01984]
Esomeprazole magnesium dihydrate [DR:D11114]
Omeprazole, clarithromycin and amoxicillin [DR:D10246]
Amoxicillin hydrate, clarithromycin and lansoprazole [DR:D08774]
Bismuth subcitrate, tetracycline and metronidazole [DR:D10245]
Amoxicillin [DR:D00229]
Clarithromycin [DR:D00276]
Omeprazole magnesium, amoxicillin and rifabutin [DR:D11858]
Other DBs
ICD-10: A49.8
MeSH: D016481
Reference
  Authors
Papadakis MA, Tierney LM (ed).
  Title
[Current Medical Diagnosis & Treatment 2004, Forty-Third Edition] (In Japanese)
  Journal
Nikkei Business Publications, Inc. (2004)
Reference
  Authors
Albaker WI
  Title
Helicobacter pylori infection and its relationship to metabolic syndrome: is it a myth or fact?
  Journal
Saudi J Gastroenterol 17:165-9 (2011)
DOI:10.4103/1319-3767.80377
Reference
  Authors
Goh KL, Chan WK, Shiota S, Yamaoka Y
  Title
Epidemiology of Helicobacter pylori infection and public health implications.
  Journal
Helicobacter 16 Suppl 1:1-9 (2011)
DOI:10.1111/j.1523-5378.2011.00874.x
Reference
  Authors
Kabir S
  Title
The current status of Helicobacter pylori vaccines: a review.
  Journal
Helicobacter 12:89-102 (2007)
DOI:10.1111/j.1523-5378.2007.00478.x
Reference
  Authors
Moss SF, Sood S
  Title
Helicobacter pylori.
  Journal
Curr Opin Infect Dis 16:445-51 (2003)
DOI:10.1097/01.qco.0000092816.64370.e2
LinkDB

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