KEGG   DISEASE: Extrinsic allergic alveolitis
H00346                      Disease                                

Extrinsic allergic alveolitis;
Hypersensitivity pneumonitis
Extrinsic allergic alveolitis (EAA), also known as hypersensitivity pneumonitis, is caused by repeated inhalation of mainly organic antigens by sensitized subjects. This induces a hypersensitivity response in the distal bronchioles and alveoli and subjects may present clinically with a variety of symptoms. EAA is caused by a wide variety of antigens including bacteria, organic materials, fungal spores, and chemicals. Of the various EAA syndromes, Farmer's lung and Bird fancier's disease are the commonest forms that have been studied. EEA is a complex dynamic clinical syndrome where clinical expression depends on the frequency and amount of contact with antigen and host susceptibility. The manifestations and symptoms can be complicated by self-regulatory measures performed by those affected individuals to reduce antigen exposure. There are many individuals with a positive antibody reaction who remain asymptomatic. EEA traditionally has been described as occurring in a state of acute, subacute, and chronic form.
Immune system disease; Respiratory disease; Infectious disease
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H00346  Extrinsic allergic alveolitis
Human diseases in ICD-11 classification [BR:br08403]
 12 Diseases of the respiratory system
  Lung diseases due to external agents
    CA70  Hypersensitivity pneumonitis due to organic dust
     H00346  Extrinsic allergic alveolitis
Env factor
Thermophilic actinomycetes (Farmer's lung)
Saccharopolyspora rectivirgula (Micropolyspora faeni) (Farmer's lung)
Thermoactinomyces vulgaris (Farmer's lung)
Thermoactinomyces sacchari (Bagassosis)
Thermoactinomycete sp. (Mushroom-worker's lung)
Agarieus hortensis spores (Mushroom-worker's lung)
Micropolyspora faeni (Humidifier lung)
Penicillium frequentans (Suberosis)
Aspergillus clavatus [GN:act] (Malt-worker's lung)
Penicillium chrysogenum (Woodworker's lung)
Penicillium casei (Cheese-washer's lung)
Cryptostroma corticale (Maple-bark stripper's lung)
Mucor stolanifer (Paprika slicer's lung)
Mycobacterium avium [GN:mao] (Hot-tub lung)
Mycobacterium intracellulare [GN:mit mir mia] (Hot-tub lung)
Trichosporon cutaneum (Summer-type hypersensitivity pneumonitis)
Candida albicans [GN:cal] (Sax lung)
Avian proteins (Bird fanciers disease)
Laboratory animals (Animal handlers lung)
Fish meal extract (Fish meal workers lung)
Rat serum proteins (Rat handlers lung)
Paints, plastics (Isocyanates)
Plastics (Anhydrides)
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Other DBs
ICD-11: CA70
ICD-10: J67
MeSH: D000542
MedlinePlus: 000109
Papadakis MA and McPhee SJ |(ed)
Current Medical Diagnosis & Treatment 2007, Forty-Sixth Edition
McGraw Hill Education
PMID:16635083 (description, env_factor)
Ismail T, McSharry C, Boyd G
Extrinsic allergic alveolitis.
Respirology 11:262-8 (2006)

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