KEGG   DISEASE: African trypanosomiasis
Entry
H00357                      Disease                                

Name
African trypanosomiasis;
Sleeping sickness
Description
African trypanosomiasis is a parasitic disease affecting both humans and livestock. It is one of the most common serious protozoan infections in sub-Saharan Africa, especially in areas of conflict. Its causative agent is Trypanosoma brucei, whose protein has been shown to induce apoptosis in human brain.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Parasitic infections (protists)
  Infections caused by Euglenozoa
   H00357  African trypanosomiasis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Parasitic diseases
   Nonintestinal protozoal diseases
    1F51  African trypanosomiasis
     H00357  African trypanosomiasis
Pathway
hsa05143  African trypanosomiasis
Pathogen
Trypanosoma brucei [GN:tbr tbg]
Comment
Vector: Glossina pallidipes (tsetse fly)
Other DBs
ICD-11: 1F51
ICD-10: B56
MeSH: D014353
MedlinePlus: 001362
Reference
  Authors
Hotez PJ, Kamath A
  Title
Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden.
  Journal
PLoS Negl Trop Dis 3:e412 (2009)
DOI:10.1371/journal.pntd.0000412
Reference
  Authors
Stiles JK, Whittaker J, Sarfo BY, Thompson WE, Powell MD, Bond VC
  Title
Trypanosome apoptotic factor mediates apoptosis in human brain vascular endothelial cells.
  Journal
Mol Biochem Parasitol 133:229-40 (2004)
DOI:10.1016/j.molbiopara.2003.10.011
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