KEGG   DISEASE: Herpes simplex virus infection
Entry
H00365                      Disease                                

Name
Herpes simplex virus infection;
HSV infection
Description
Herpes simplex virus infection is caused by Herpes simplex virus type 1 (HSV-1) and Herpes simplex virus type 2 (HSV-2), Simplex viruses in the order Herpesvirales of dsDNA viruses. Humans are the only natural host and reservoir for the HSV virus. HSV are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. HSV infects the human host via mucosal surfaces or damaged skin, and most primary infections are asymptomatic. HSV-1 is mainly associated with orofacial lesions, yet it is also the cause of infectious blindness and viral encephalitis in adults. HSV-2 is mainly associated with genital lesions and neonatal encephalitis.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00365  Herpes simplex virus infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Predominantly sexually transmitted infections
   1A94  Anogenital herpes simplex infection
    H00365  Herpes simplex virus infection
  Viral infections characterised by skin or mucous membrane lesions
   1F00  Herpes simplex infections
    H00365  Herpes simplex virus infection
Pathway
hsa05168  Herpes simplex virus 1 infection
Network
nt06114  PI3K signaling (viruses)
nt06121  TLR signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06129  MHC presentation (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06133  RIG-I signaling (viruses)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06136  Complement activation (viruses)
nt06137  OAS/RNase L pathway (viruses)
nt06138  PKR-eIF2alpha signaling (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00560  HSV gD to HVEM-NFKB signaling pathway
N00561  HSV ICP0 to TLR2/4-NFKB signaling pathway
N00562  HSV US3 to TLR2/4-NFKB signaling pathway
N00564  HSV US3 to TLR3-NFKB signaling pathway
N00565  HSV US11 to RIG-I-like receptor signaling pathway
N00566  HSV UL36USP to RIG-I-like receptor signaling pathway
N00567  HSV ICP34.5 to TBK1 signaling pathway
N00568  HSV US3 to IRF3 signaling pathway
N00569  HSV UL41 to cGAS-STING signaling pathway
N00570  HSV ICP0 to cGAS-STING signaling pathway
N00572  HSV ICP34.5 to PKR-eIF2alpha signaling pathway
N00573  HSV US11 to PKR-eIF2alpha signaling pathway
N00574  HSV US11 to oligoadenylate synthetase (OAS)/RNase L pathway
N00575  HSV ICP27 to IFN signaling pathway
N00576  HSV UL41/UL13 to IFN signaling pathway
N00577  HSV UL41 to IFN signaling pathway
N00578  HSV UL41 to IFN signaling pathway
N00579  HSV ICP6 to extrinsic apoptotic pathway
N00580  HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00581  HSV ICP47 to antigen processing and presentation by MHC class I molecules
N00583  HSV VP11/12 to PI3K signaling pathway
N00584  HSV US3 to MTOR signaling pathway
N00585  HSV US3 to intrinsic apoptotic pathway
N00587  HSV ICP27 to Nuclear export of mRNA
N00588  HSV VP16 to Oct-1-mediated transcription
N00589  HSV gC to alternative pathway of complement activation
N00591  HSV gB to antigen processing and presentation by MHC class II molecules
N00592  HSV ICP0 to p53-mediated transcription
N01186  HSV1 SgG1 to CCR signaling
N01187  HSV2 SgG2 to CCR signaling
N01192  HSV2 SgG2 to CCR signaling
N01222  HSV1 SgG1 to CCR signaling
N01223  HSV2 SgG2 to CCR signaling
N01227  HSV1 SgG1 to CCR signaling
N01228  HSV2 SgG2 to CCR signaling
N01244  HSV1 SgG1 to CXCR signaling
N01245  HSV2 SgG2 to CXCR signaling
N01249  HSV1 SgG1 to CXCR signaling
N01250  HSV2 SgG2 to CXCR signaling
N01256  HSV1 SgG1 to CXCR signaling
N01257  HSV2 SgG2 to CXCR signaling
Pathogen
Human herpesvirus 1 [GN:T40073]
Human herpesvirus 2 [GN:T40074]
Drug
Acyclovir [DR:D00222]
Acyclovir sodium [DR:D02764]
Penciclovir [DR:D05407]
Ganciclovir [DR:D00333]
Famciclovir [DR:D00317]
Valacyclovir hydrochloride [DR:D00398]
Foscarnet sodium [DR:D00579]
Trifluridine [DR:D00391]
Acyclovir and hydrochortisone [DR:D11627]
Other DBs
ICD-11: 1A94 1F00
ICD-10: B00 A60 O26.4 P35.2
MeSH: D006561
MedlinePlus: 001324
Reference
  Authors
Steiner I, Benninger F
  Title
Update on herpes virus infections of the nervous system.
  Journal
Curr Neurol Neurosci Rep 13:414 (2013)
DOI:10.1007/s11910-013-0414-8
Reference
  Authors
Hill GM, Ku ES, Dwarakanathan S
  Title
Herpes simplex keratitis.
  Journal
Dis Mon 60:239-46 (2014)
DOI:10.1016/j.disamonth.2014.03.003
Reference
  Authors
Tognarelli EI, Palomino TF, Corrales N, Bueno SM, Kalergis AM, Gonzalez PA
  Title
Herpes Simplex Virus Evasion of Early Host Antiviral Responses.
  Journal
Front Cell Infect Microbiol 9:127 (2019)
DOI:10.3389/fcimb.2019.00127
Reference
  Authors
Chisholm C, Lopez L
  Title
Cutaneous infections caused by Herpesviridae: a review.
  Journal
Arch Pathol Lab Med 135:1357-62 (2011)
DOI:10.5858/arpa.2010-0156-RS
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