KEGG   DISEASE: Herpes simplex virus infectionHelp
Entry
H00365                      Disease                                

Name
Herpes simplex virus infection;
HSV infection
Description
Herpes simplex viruses (HSV-1 and HSV-2) are responsible for long-term latent infections causing recurrent painful blisters on an erythematous base. HSV-1 and HSV-2 are the usual cause of herpes labialis and herpes genitalis, respectively. However It is now widely accepted that HSV-1 is an important cause for genital herpes. Infection can also occur in other parts of the body such as the brain (called herpes encephalitis), spinal cord (called herpes meningitis), cornea of the eye (called herpes simplex keratitis) and skin (called eczema herpeticum) if the immune system is severely defective or compromised. HSV spreads through direct contact. Most HSV infection are asymptomatic. However when symptoms do occur, they tend to be more severe with primary compared with recurrent infections. An initial episode of herpes may produce a systemic prodrome of fever and malaise.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00365  Herpes simplex virus infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Predominantly sexually transmitted infections
   1A94  Anogenital herpes simplex infection
    H00365  Herpes simplex virus infection
  Viral infections characterised by skin or mucous membrane lesions
   1F00  Herpes simplex infections
    H00365  Herpes simplex virus infection
BRITE hierarchy
Pathway
hsa05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
  Element
N00560  HSV gD to HVEM-NFKB signaling pathway
N00561  HSV ICP0 to TLR2/4-NFKB signaling pathway
N00562  HSV US3 to TLR2/4-NFKB signaling pathway
N00564  HSV US3 to TLR3-NFKB signaling pathway
N00565  HSV US11 to RIG-I-like receptor signaling pathway
N00566  HSV UL36USP to RIG-I-like receptor signaling pathway
N00567  HSV ICP34.5 to TBK1 signaling pathway
N00568  HSV US3 to IRF3 signaling pathway
N00569  HSV UL41 to cGAS-STING signaling pathway
N00570  HSV ICP0 to cGAS-STING signaling pathway
N00572  HSV ICP34.5 to PKR-eIF2alpha signaling pathway
N00573  HSV US11 to PKR-eIF2alpha signaling pathway
N00574  HSV US11 to oligoadenylate synthetase (OAS)/RNase L pathway
N00575  HSV ICP27 to IFN signaling pathway
N00576  HSV UL41/UL13 to IFN signaling pathway
N00577  HSV UL41 to IFN signaling pathway
N00578  HSV UL41 to IFN signaling pathway
N00579  HSV ICP6 to extrinsic apoptotic pathway
N00580  HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00581  HSV ICP47 to antigen processing and presentation by MHC class I molecules
N00583  HSV VP11/12 to PI3K signaling pathway
N00584  HSV US3 to MTOR signaling pathway
N00585  HSV US3 to intrinsic apoptotic pathway
N00587  HSV ICP27 to Nuclear export of mRNA
N00588  HSV VP16 to Oct-1-mediated transcription
N00589  HSV gC to alternative pathway of complement activation
N00591  HSV gB to antigen processing and presentation by MHC class II molecules
N00592  HSV ICP0 to p53-mediated transcription
Pathogen
Human herpesvirus 1 [GN:T40073]
Human herpesvirus 2 [GN:T40074]
Drug
Acyclovir [DR:D00222]
Acyclovir sodium [DR:D02764]
Penciclovir [DR:D05407]
Ganciclovir [DR:D00333]
Famciclovir [DR:D00317]
Valacyclovir hydrochloride [DR:D00398]
Foscarnet sodium [DR:D00579]
Trifluridine [DR:D00391]
Acyclovir and hydrochortisone [DR:D11627]
Other DBs
ICD-11: 1A94 1F00
ICD-10: B00 A60 O26.4 P35.2
MeSH: D006561
MedlinePlus: 001324
Reference
PMID:21970493 (description, env_factor)
  Authors
Chisholm C, Lopez L
  Title
Cutaneous infections caused by Herpesviridae: a review.
  Journal
Arch Pathol Lab Med 135:1357-62 (2011)
DOI:10.5858/arpa.2010-0156-RS
Reference
PMID:18541820 (drug)
  Authors
Cernik C, Gallina K, Brodell RT
  Title
The treatment of herpes simplex infections: an evidence-based review.
  Journal
Arch Intern Med 168:1137-44 (2008)
DOI:10.1001/archinte.168.11.1137
Reference
  Authors
Hill GM, Ku ES, Dwarakanathan S
  Title
Herpes simplex keratitis.
  Journal
Dis Mon 60:239-46 (2014)
DOI:10.1016/j.disamonth.2014.03.003
Reference
  Authors
Steiner I, Benninger F
  Title
Update on herpes virus infections of the nervous system.
  Journal
Curr Neurol Neurosci Rep 13:414 (2013)
DOI:10.1007/s11910-013-0414-8
Reference
  Authors
Steiner I
  Title
Herpes simplex virus encephalitis: new infection or reactivation?
  Journal
Curr Opin Neurol 24:268-74 (2011)
DOI:10.1097/WCO.0b013e328346be6f
Reference
PMID:4361958
  Authors
Morrison RE, Miller MH, Lyon LW, Griffiss JM, Artenstein MS
  Title
Adult meningoencephalitis caused by herpesvirus hominis type 2.
  Journal
Am J Med 56:540-4 (1974)
DOI:10.1016/0002-9343(74)90486-0
Reference
  Authors
Liaw FY, Huang CF, Hsueh JT, Chiang CP
  Title
Eczema herpeticum: a medical emergency.
  Journal
Can Fam Physician 58:1358-61 (2012)
DOI:10.3928/00904481-20100922-05
Reference
  Authors
Rowe AM, St Leger AJ, Jeon S, Dhaliwal DK, Knickelbein JE, Hendricks RL
  Title
Herpes keratitis.
  Journal
Prog Retin Eye Res 32:88-101 (2013)
DOI:10.1016/j.preteyeres.2012.08.002
Reference
  Authors
Berardi A, Lugli L, Rossi C, Maria CL, Guidotti I, Gallo C, Ferrari F
  Title
Neonatal herpes simplex virus.
  Journal
J Matern Fetal Neonatal Med 24 Suppl 1:88-90 (2011)
DOI:10.3109/14767058.2011.607560
Reference
  Authors
Desselberger U
  Title
Herpes simplex virus infection in pregnancy: diagnosis and significance.
  Journal
Intervirology 41:185-90 (1998)
DOI:10.1159/000024934
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