KEGG DISEASE: Herpes simplex virus infection

DISEASE: Herpes simplex virus infection

Entry

H00365 Disease

Name

Herpes simplex virus infection;
HSV infection

Description

Herpes simplex viruses (HSV-1 and HSV-2) are responsible for long-term latent infections causing recurrent painful blisters on an erythematous base. HSV-1 and HSV-2 are the usual cause of herpes labialis and herpes genitalis, respectively. However It is now widely accepted that HSV-1 is an important cause for genital herpes. Infection can also occur in other parts of the body such as the brain (called herpes encephalitis), spinal cord (called herpes meningitis), cornea of the eye (called herpes simplex keratitis) and skin (called eczema herpeticum) if the immune system is severely defective or compromised. HSV spreads through direct contact. Most HSV infection are asymptomatic. However when symptoms do occur, they tend to be more severe with primary compared with recurrent infections. An initial episode of herpes may produce a systemic prodrome of fever and malaise.

Category

Infectious disease

Brite

Infectious diseases [BR:br08401]
Viral infections
  Infections caused by dsDNA viruses
   H00365  Herpes simplex virus infection
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
  Predominantly sexually transmitted infections
   1A94  Anogenital herpes simplex infection
    H00365  Herpes simplex virus infection
  Viral infections characterised by skin or mucous membrane lesions
   1F00  Herpes simplex infections
    H00365  Herpes simplex virus infection

Pathway

hsa05168

Herpes simplex virus 1 infection

Network

nt06168 Herpes simplex virus 1 (HSV-1)

Element

N00560

HSV gD to HVEM-NFKB signaling pathway

N00561

HSV ICP0 to TLR2/4-NFKB signaling pathway

N00562

HSV US3 to TLR2/4-NFKB signaling pathway

N00564

HSV US3 to TLR3-NFKB signaling pathway

N00565

HSV US11 to RIG-I-like receptor signaling pathway

N00566

HSV UL36USP to RIG-I-like receptor signaling pathway

N00567

HSV ICP34.5 to TBK1 signaling pathway

N00568

HSV US3 to IRF3 signaling pathway

N00569

HSV UL41 to cGAS-STING signaling pathway

N00570

HSV ICP0 to cGAS-STING signaling pathway

N00572

HSV ICP34.5 to PKR-eIF2alpha signaling pathway

N00573

HSV US11 to PKR-eIF2alpha signaling pathway

N00574

HSV US11 to oligoadenylate synthetase (OAS)/RNase L pathway

N00575

HSV ICP27 to IFN signaling pathway

N00576

HSV UL41/UL13 to IFN signaling pathway

N00577

HSV UL41 to IFN signaling pathway

N00578

HSV UL41 to IFN signaling pathway

N00579

HSV ICP6 to extrinsic apoptotic pathway

N00580

HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways

N00581

HSV ICP47 to antigen processing and presentation by MHC class I molecules

N00583

HSV VP11/12 to PI3K signaling pathway

N00584

HSV US3 to MTOR signaling pathway

N00585

HSV US3 to intrinsic apoptotic pathway

N00587

HSV ICP27 to Nuclear export of mRNA

N00588

HSV VP16 to Oct-1-mediated transcription

N00589

HSV gC to alternative pathway of complement activation

N00591

HSV gB to antigen processing and presentation by MHC class II molecules

N00592

HSV ICP0 to p53-mediated transcription

Pathogen

Human herpesvirus 1 [GN:T40073]
Human herpesvirus 2 [GN:T40074]

Drug

Acyclovir [DR:D00222]
Acyclovir sodium [DR:D02764]
Penciclovir [DR:D05407]
Ganciclovir [DR:D00333]
Famciclovir [DR:D00317]
Valacyclovir hydrochloride [DR:D00398]
Foscarnet sodium [DR:D00579]
Trifluridine [DR:D00391]
Acyclovir and hydrochortisone [DR:D11627]

Other DBs

ICD-11:

ICD-10:

MeSH:

MedlinePlus:

Reference

PMID:21970493 (description, env_factor)

Authors