KEGG   DISEASE: Cytomegalovirus infectionHelp
Entry
H00368                      Disease                                

Name
Cytomegalovirus infection;
CMV infection
Description
Cytomegalovirus (CMV) is a double-stranded DNA virus of the Herpesviridae family acquired by late childhood in the majority of individuals. Primary infection is nonspecific but after that the virus becomes latent in multiple organs and can later be reactivated. CMV is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS or transplant recipients on immunosuppressive therapy.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00368  Cytomegalovirus infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Certain other viral diseases
   1D82  Cytomegaloviral disease
    H00368  Cytomegalovirus infection
BRITE hierarchy
Pathway
hsa05163  Human cytomegalovirus infection
Network
N00385  HCMV gB to PDGFR-PI3K signaling pathway
N00386  HCMV gB to PDGFR-RAS-ERK signaling pathway
N00387  HCMV IE1-72/IE2-86 to PI3K signaling pathway
N00388  HCMV UL38 to MTOR signaling pathway
N00389  HCMV IE1-72 to transcription
N00391  HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00392  HCMV gB to EGFR-RAS-ERK signaling pathway
N00394  HCMV gH to ITGA/B-RhoA signaling pathway
N00396  HCMV UL82 to cGAS-STING signaling pathway
N00397  HCMV UL26 to NFKB signaling pathway
N00398  HCMV IE2-86 to TNF-NFKB signaling pathway
N00400  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway
N00402  HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway
N00404  HCMV US28 to GNAI-AC-PKA signaling pathway
N00406  HCMV US28 to GNA12/13-Rho signaling pathway
N00407  HCMV UL33 to GNAQ-PLCB/G-calcineurin signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00411  HCMV UL33 to GNAS-AC-PKA signaling pathway
N00412  HCMV UL33 to GNAI-AC-PKA signaling pathway
N00414  HCMV US27 to CXCR4-GNB/G-PLCB-PKC signaling pathway
N00416  HCMV IL10 to IL10-JAK-STAT signaling pathway
N00417  HCMV US6 to antigen processing and presentation by MHC class I molecules
N00418  HCMV US2/11 to antigen processing and presentation by MHC class I molecules
N00419  HCMV US3/10 to antigen processing and presentation by MHC class I molecules
N00420  HCMV IE2-86 to p21-cell cycle G1/S
N00421  HCMV IE2-86 to p21-cell cycle G1/S
N00422  HCMV IE2-86 to cell cycle G1/S
N00423  HCMV IE1-72 to cell cycle G1/S
N00424  HCMV pp71 to cell cycle G1/S
N00425  HCMV UL36 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00426  HCMV UL37x1 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00427  HCMV vCXCL to CXCR-GNB/G-PI3K-AKT signaling pathway
N00429  HCMV UL22A to CCR5-GNB/G-PLCB/G-PKC signaling pathway
 » show all
Pathogen
Human herpesvirus 5 (Human cytomegalovirus) [GN:T40080]
Drug
Ganciclovir [DR:D00333]
Ganciclovir sodium [DR:D04301]
Cidofovir [DR:D00273]
Valganciclovir hydrochloride [DR:D03256]
Foscarnet sodium [DR:D00579]
Letermovir [DR:D10801]
Other DBs
ICD-11: 1D82
ICD-10: B20.2 B25 B27.1 P35.1
MeSH: D003586
Reference
PMID:21970493 (env_factor, marker)
  Authors
Chisholm C, Lopez L
  Title
Cutaneous infections caused by Herpesviridae: a review.
  Journal
Arch Pathol Lab Med 135:1357-62 (2011)
DOI:10.5858/arpa.2010-0156-RS
Reference
  Authors
Fishman JA
  Title
Infections in immunocompromised hosts and organ transplant recipients: essentials.
  Journal
Liver Transpl 17 Suppl 3:S34-7 (2011)
DOI:10.1002/lt.22378
Reference
  Authors
Jackson SE, Mason GM, Wills MR
  Title
Human cytomegalovirus immunity and immune evasion.
  Journal
Virus Res 157:151-60 (2011)
DOI:10.1016/j.virusres.2010.10.031
Reference
PMID:21841300 (drug)
  Authors
Jain M, Duggal S, Chugh TD
  Title
Cytomegalovirus infection in non-immunosuppressed critically ill patients.
  Journal
J Infect Dev Ctries 5:571-9 (2011)
DOI:10.3855/jidc.1487
Reference
PMID:21827433 (marker)
  Authors
Ross SA, Novak Z, Pati S, Boppana SB
  Title
Overview of the diagnosis of cytomegalovirus infection.
  Journal
Infect Disord Drug Targets 11:466-74 (2011)
DOI:10.2174/187152611797636703
LinkDB All DBs

» Japanese version

DBGET integrated database retrieval system