| Entry |
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| Name |
Cytomegalovirus infection;
CMV infection |
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| Description |
Cytomegalovirus (CMV) is a double-stranded DNA virus of the Herpesviridae family acquired by late childhood in the majority of individuals. Primary infection is nonspecific but after that the virus becomes latent in multiple organs and can later be reactivated. CMV is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS or transplant recipients on immunosuppressive therapy.
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| Category |
Infectious disease
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| Brite |
Infectious diseases [BR:br08401]
Viral infections
Infections caused by dsDNA viruses
H00368 Cytomegalovirus infection
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
Certain other viral diseases
1D82 Cytomegaloviral disease
H00368 Cytomegalovirus infection
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| Pathway |
| hsa05163 | Human cytomegalovirus infection |
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| Network |
nt06110 MAPK signaling (viruses and bacteria) nt06114 PI3K signaling (viruses) nt06119 JAK-STAT signaling (viruses) nt06123 TNF signaling (viruses and bacteria) nt06124 Chemokine signaling (viruses) nt06129 MHC presentation (viruses) nt06130 Cell cycle (viruses) nt06131 Apoptosis (viruses and bacteria) nt06134 CGAS-STING signaling (viruses and bacteria) nt06135 Cytoskeletal regulation (viruses and bacteria) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06167 Human cytomegalovirus (HCMV) |
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| Element |
| N00385 | HCMV gB to PDGFR-PI3K signaling pathway |
| N00386 | HCMV gB to PDGFR-RAS-ERK signaling pathway |
| N00387 | HCMV IE1-72/IE2-86 to PI3K signaling pathway |
| N00388 | HCMV UL38 to MTOR signaling pathway |
| N00389 | HCMV IE1-72 to transcription |
| N00391 | HCMV gB to EGFR-PI3K-NFKB signaling pathway |
| N00392 | HCMV gB to EGFR-RAS-ERK signaling pathway |
| N00394 | HCMV gH to ITGA/B-RhoA signaling pathway |
| N00396 | HCMV UL82 to cGAS-STING signaling pathway |
| N00397 | HCMV UL26 to NFKB signaling pathway |
| N00398 | HCMV IE2-86 to TNF-NFKB signaling pathway |
| N00400 | HCMV US28 to GNB/G-PI3K-NFKB signaling pathway |
| N00402 | HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway |
| N00404 | HCMV US28 to GNAI-AC-PKA signaling pathway |
| N00406 | HCMV US28 to GNA12/13-Rho signaling pathway |
| N00407 | HCMV UL33 to GNAQ-PLCB/G-calcineurin signaling pathway |
| N00409 | HCMV UL33 to GNB/G-Rho signaling pathway |
| N00411 | HCMV UL33 to GNAS-AC-PKA signaling pathway |
| N00412 | HCMV UL33 to GNAI-AC-PKA signaling pathway |
| N00414 | HCMV US27 to CXCR4-GNB/G-PLCB-PKC signaling pathway |
| N00416 | HCMV vIL10 to IL10-JAK-STAT signaling pathway |
| N00417 | HCMV US6 to antigen processing and presentation by MHC class I molecules |
| N00418 | HCMV US2/11 to antigen processing and presentation by MHC class I molecules |
| N00419 | HCMV US3/10 to antigen processing and presentation by MHC class I molecules |
| N00420 | HCMV IE2-86 to p21-cell cycle G1/S |
| N00421 | HCMV IE2-86 to p21-cell cycle G1/S |
| N00422 | HCMV IE2-86 to cell cycle G1/S |
| N00423 | HCMV IE1-72 to cell cycle G1/S |
| N00424 | HCMV pp71 to cell cycle G1/S |
| N00425 | HCMV UL36 to crosstalk between extrinsic and intrinsic apoptotic pathways |
| N00426 | HCMV UL37x1 to crosstalk between extrinsic and intrinsic apoptotic pathways |
| N00427 | HCMV vCXCL to CXCR-GNB/G-PI3K-AKT signaling pathway |
| N00429 | HCMV UL22A to CCR5-GNB/G-PLCB/G-PKC signaling pathway |
| N01168 | CCL3/7 to HCMV US28 signaling |
| N01175 | CCL2 to HCMV US28 signaling |
| N01183 | CCL5/11/13/26/28 to HCMV US28 signaling |
| N01212 | CCL4 to HCMV US28 signaling |
| N01237 | HCMV vCXCL1 to CXCR1 signaling |
| N01262 | CX3CL1 to HCMV US28 signaling |
| N01264 | HCMV vCXCL1 to CX3CR1 signaling |
| N01279 | HCMV UL141 to DR5 signaling |
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| Pathogen |
Human herpesvirus 5 (Human cytomegalovirus) [GN: T40080] |
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| Drug |
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| Other DBs |
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| Reference |
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| Authors |
Chisholm C, Lopez L |
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| Title |
Cutaneous infections caused by Herpesviridae: a review. |
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| Journal |
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| Reference |
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| Authors |
Fishman JA |
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| Title |
Infections in immunocompromised hosts and organ transplant recipients: essentials. |
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| Journal |
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| Reference |
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| Authors |
Jackson SE, Mason GM, Wills MR |
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| Title |
Human cytomegalovirus immunity and immune evasion. |
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| Journal |
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| Reference |
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| Authors |
Jain M, Duggal S, Chugh TD |
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| Title |
Cytomegalovirus infection in non-immunosuppressed critically ill patients. |
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| Journal |
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| Reference |
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| Authors |
Ross SA, Novak Z, Pati S, Boppana SB |
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| Title |
Overview of the diagnosis of cytomegalovirus infection. |
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| Journal |
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| LinkDB |
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