KEGG   DISEASE: Rheumatoid arthritisHelp
Entry
H00630                      Disease                                

Name
Rheumatoid arthritis
Description
Rheumatoid arthritis (RA) is a common autoimmune disease that primarily manifests as chronic inflammatory arthropathy. Persistent synovitis leads to cartilage destruction, bone erosions and periarticular decalcification, subsequently resulting in impaired joint function. It is more common between the ages of 35 and 50 years, affecting three times more women than men. Susceptibility to RA is genetically determined with multiple genes contributing. Inheritance of HLA DRB1 alleles encoding a distinctive five-amino-acid sequence known as the "shared epitope" (SE) is the best characterized genetic risk factor. The mechanism by which the SE alleles contribute to the development of RA is not very clear. It has been postulated that the presence of these conserved sequences in the antigen-binding groove alters the way antigenic peptides are bound to and presented to T-cell lymphocytes. This, in turn, may trigger abnormal immune responses and lead to RA.
Category
Autoimmune disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H00630  Rheumatoid arthritis
Human diseases in ICD-11 classification [BR:br08403]
 15 Diseases of the musculoskeletal system or connective tissue
  Arthropathies
   Inflammatory arthropathies
    FA20  Rheumatoid arthritis
     H00630  Rheumatoid arthritis
BRITE hierarchy
Pathway
hsa05323  Rheumatoid arthritis
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Sulfasalazine [DR:D00448]
Indomethacin [DR:D00141]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Corticotropin [DR:D00146]
Cortisone acetate [DR:D00973]
Methotrexate [DR:D00142]
Methotrexate sodium [DR:D02115]
Rituximab [DR:D02994]
Leflunomide [DR:D00749]
Abatacept [DR:D03203]
Tofacitinib citrate [DR:D09783]
Baricitinib [DR:D10308]
Upadacitinib hydrate [DR:D11048]
Etanercept [DR:D00742]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Certolizumab pegol [DR:D03441]
Golimumab [DR:D04358]
Anakinra [DR:D02934]
Tocilizumab [DR:D02596]
Sarilumab [DR:D10161]
Cyclosporine [DR:D00184]
Azathioprine [DR:D00238]
Diclofenac sodium and misoprostol [DR:D11091]
Piroxicam [DR:D00127]
Fenoprofen calcium [DR:D00968]
Flurbiprofen [DR:D00330]
Oxaprozin [DR:D00463]
Ibuprofen and famotidine [DR:D11575]
Naproxen and esomeprazole magnesium [DR:D11576]
Meclofenamate sodium [DR:D00169]
Auranofin [DR:D00237]
Salsalate [DR:D00428]
Hydroxychloroquine sulfate [DR:D02114]
Lobenzarit sodium [DR:D01808]
Other DBs
ICD-11: FA20
ICD-10: M05
MeSH: D001172
Reference
PMID:27338350 (gene, drug)
  Authors
Chung IM, Ketharnathan S, Thiruvengadam M, Rajakumar G
  Title
Rheumatoid Arthritis: The Stride from Research to Clinical Practice.
  Journal
Int J Mol Sci 17:E900 (2016)
DOI:10.3390/ijms17060900
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
  Journal
McGraw Hill Education
Reference
PMID:23998731 (drug)
  Authors
Meier FM, Frerix M, Hermann W, Muller-Ladner U
  Title
Current immunotherapy in rheumatoid arthritis.
  Journal
Immunotherapy 5:955-74 (2013)
DOI:10.2217/imt.13.94
Reference
  Authors
Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac'h N, Falgarone G
  Title
Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction.
  Journal
J Autoimmun 39:222-8 (2012)
DOI:10.1016/j.jaut.2012.05.021
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