KEGG   DISEASE: Tourette syndrome
Entry
H00862                      Disease                                

Name
Tourette syndrome
Description
Tourette's syndrome (TS) is a developmental neuropsychiatric disorder characterized by chronic motor and vocal tics. Rare functional variants in the neuronal transmembrane molecule SLITRK1 have been associated with TS. The SLITRK1 gene is expressed in brain regions and it appears to play a role in dendritic growth. Another possible rare genetic cause of TS is a mutation in the HDC gene. The HDC gene encodes for L-histidine decarboxylase, which is the rate-limiting enzyme that catalyzes the biosynthesis of histamine from histidine.
Category
Mental and behavioural disorder
Brite
Human diseases [BR:br08402]
 Other diseases
  Mental and behavioural disorders
   H00862  Tourette syndrome
Human diseases in ICD-11 classification [BR:br08403]
 08 Diseases of the nervous system
  Movement disorders
   8A05  Tic disorders
    H00862  Tourette syndrome
Pathway
hsa00340  Histidine metabolism
Gene
SLITRK1 [HSA:114798]
HDC [HSA:3067] [KO:K01590]
Drug
Haloperidol [DR:D00136]
Haloperidol lactate [DR:D08035]
Pimozide [DR:D00560]
Other DBs
ICD-11: 8A05.00
ICD-10: F95.2
MeSH: D005879
OMIM: 137580
Reference
  Authors
Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Morgan TM, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Gunel M, State MW
  Title
L-histidine decarboxylase and Tourette's syndrome.
  Journal
N Engl J Med 362:1901-8 (2010)
DOI:10.1056/NEJMoa0907006
Reference
  Authors
Katayama K, Yamada K, Ornthanalai VG, Inoue T, Ota M, Murphy NP, Aruga J
  Title
Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities.
  Journal
Mol Psychiatry 15:177-84 (2010)
DOI:10.1038/mp.2008.97
Reference
  Authors
State MW
  Title
The genetics of Tourette disorder.
  Journal
Curr Opin Genet Dev 21:302-9 (2011)
DOI:10.1016/j.gde.2011.01.007
Reference
PMID:21386676 (Drug)
  Authors
Bloch M, State M, Pittenger C
  Title
Recent advances in Tourette syndrome.
  Journal
Curr Opin Neurol 24:119-25 (2011)
DOI:10.1097/WCO.0b013e328344648c
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