KEGG   DISEASE: Ovarian hyperstimulation syndrome
Entry
H01039                      Disease                                

Name
Ovarian hyperstimulation syndrome
Description
Ovarian hyperstimulation syndrome (OHSS) is typically an iatrogenic complication of ovulation induction (OI) occurring during the luteal phase or early pregnancy. OHSS is characterised by a cystic enlargement of the ovaries and an acute fluid shift from the intravascular to the third space, which may result in ascites, pleural infusions, pericardial infusion, and even generalized edema. Majority of OHSS cases have been associated with the use of gonadotrophins for OI in anovulatory women or for ovarian stimulation (OS) in the context of assisted reproductive technology (ART). Recurrent cases and familial occurrence of OHSS have been described, and different mutations in the follicle-stimulating hormone receptor (FSHr) have been reported in these cases. Polycystic ovarian syndrome (PCOS) appears to be the major predisposing factor for OHSS in a large number of studies.
Category
Reproductive system disease
Brite
Human diseases [BR:br08402]
 Reproductive system diseases
  Reproductive system diseases
   H01039  Ovarian hyperstimulation syndrome
Human diseases in ICD-11 classification [BR:br08403]
 16 Diseases of the genitourinary system
  Diseases of the female genital system
   GA32  Complications associated with medically assisted reproduction
    H01039  Ovarian hyperstimulation syndrome
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Gene
FSHR [HSA:2492] [KO:K04247]
Env factor
Medication for ovulation induction or ovarian stimulation
Other DBs
ICD-11: GA32.0
ICD-10: N98.1
MeSH: D016471
OMIM: 608115
Reference
  Authors
Kasum M
  Title
New insights in mechanisms for development of ovarian hyperstimulation syndrome.
  Journal
Coll Antropol 34:1139-43 (2010)
Reference
PMID:19632900 (description, gene, environmental factor)
  Authors
Vloeberghs V, Peeraer K, Pexsters A, D'Hooghe T
  Title
Ovarian hyperstimulation syndrome and complications of ART.
  Journal
Best Pract Res Clin Obstet Gynaecol 23:691-709 (2009)
DOI:10.1016/j.bpobgyn.2009.02.006
Reference
  Authors
Humaidan P, Quartarolo J, Papanikolaou EG
  Title
Preventing ovarian hyperstimulation syndrome: guidance for the clinician.
  Journal
Fertil Steril 94:389-400 (2010)
DOI:10.1016/j.fertnstert.2010.03.028
Reference
  Title
Ovarian hyperstimulation syndrome.
  Journal
Fertil Steril 86:S178-83 (2006)
DOI:10.1016/j.fertnstert.2006.08.021
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