KEGG   DISEASE: Asthma with nasal polyps and aspirin intolerance
Entry
H01191                      Disease                                

Name
Asthma with nasal polyps and aspirin intolerance
Description
Asthma is a phenotypically heterogeneous disorder with many etiologic factors and clinical characteristics. In some patients with asthma, aspirin and all nonsteroidal anti-inflammatory drugs (NSAIDs) trigger asthmatic attacks. This clinical syndrome is characterized by eosinophilic inflammation of nasal and bronchial tissue, often associated with nasal polyps. It has been reported that genetic variations in TBX21 are associated with susceptibility to asthma with nasal polyps and aspirin intolerance.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01191  Asthma with nasal polyps and aspirin intolerance
Human diseases in ICD-11 classification [BR:br08403]
 12 Diseases of the respiratory system
  Certain lower respiratory tract diseases
   CA23  Asthma
    H01191  Asthma with nasal polyps and aspirin intolerance
Gene
TBX21 [HSA:30009] [KO:K10166]
PTGER2 [HSA:5732] [KO:K04259]
Other DBs
ICD-11: CA23.20
ICD-10: J45
MeSH: C565935
OMIM: 208550
Reference
  Authors
Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T
  Title
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.
  Journal
Hum Genet 117:16-26 (2005)
DOI:10.1007/s00439-005-1285-0
Reference
  Authors
Schaper C, Noga O, Koch B, Ewert R, Felix SB, Glaser S, Kunkel G, Gustavus B
  Title
Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.
  Journal
J Investig Allergol Clin Immunol 21:51-8 (2011)
Reference
  Authors
Jinnai N, Sakagami T, Sekigawa T, Kakihara M, Nakajima T, Yoshida K, Goto S, Hasegawa T, Koshino T, Hasegawa Y, Inoue H, Suzuki N, Sano Y, Inoue I
  Title
Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach.
  Journal
Hum Mol Genet 13:3203-17 (2004)
DOI:10.1093/hmg/ddh332
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