KEGG   DISEASE: Hypochromic microcytic anemiaHelp
Entry
H01196                      Disease                                

Name
Hypochromic microcytic anemia
Description
Hypochromic microcytic anemia has been associated with a defect of iron absorption due to reduced iron entry into intestinal cells. Several isoforms of NRAMP2 (SLC11A2) are expressed ubiquitously in recycling endosomes or specifically at the apical membrane of epithelial cells in intestine and kidneys, and can contribute to iron overload, whereas mutations impairing NRAMP2 function cause a form of congenital hypochromic microcytic anemia.
Category
Hematologic disease
Brite
Human diseases [BR:br08402]
 Cardiovascular diseases
  Hematologic diseases
   H01196  Hypochromic microcytic anemia
Human diseases in ICD-11 classification [BR:br08403]
 03 Diseases of the blood or blood-forming organs
  Anaemias or other erythrocyte disorders
   Nutritional or metabolic anaemias
    3A00  Iron deficiency anaemia
     H01196  Hypochromic microcytic anemia
BRITE hierarchy
Pathway
hsa04142  Lysosome
hsa04978  Mineral absorption
Gene
NRAMP2 [HSA:4891] [KO:K21398]
Other DBs
ICD-11: 3A00.Y
ICD-10: D50.8
OMIM: 206100
Reference
  Authors
Courville P, Chaloupka R, Cellier MF
  Title
Recent progress in structure-function analyses of Nramp proton-dependent metal-ion transporters.
  Journal
Biochem Cell Biol 84:960-78 (2006)
DOI:10.1139/o06-193
Reference
PMID:9808632
  Authors
Wood RJ, Han O
  Title
Recently identified molecular aspects of intestinal iron absorption.
  Journal
J Nutr 128:1841-4 (1998)
DOI:10.1093/jn/128.11.1841
LinkDB All DBs

» Japanese version

DBGET integrated database retrieval system