Hyperalphalipoproteinemia (HALP) is a condition of elevated high-density lipoprotein cholesterol (HDL-C) level caused by a variety of genetic and environmental factors. The most important cause of primary HALP is a genetic deficiency of CETP, which has been reported mainly from Japan. A mutation in APOC3 gene is also associated in some families. Familial HALP often coexists with longevity, and that higher HDL-C levels are found among healthy elderly. HALP is also associated with some diseases. Recent studies have shown that hetero and homozygosity for CETP gene mutations is associated with an increased coronary artery disease (CAD) risk.
Inherited metabolic disease; Hematologic disease
Human diseases [BR:
Congenital disorders of metabolism
Congenital disorders of lipid/glycolipid metabolism
Human diseases in ICD-11 classification [BR:
05 Endocrine, nutritional or metabolic diseases
Disorders of lipoprotein metabolism or certain specified lipidaemias
PPAR signaling pathway
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