KEGG   DISEASE: Dental caries
Entry
H01331                      Disease                                

Name
Dental caries;
Dental decay
Description
Dental caries occurs due to demineralization of enamel and dentine (the hard tissues of the teeth) by organic acids formed by bacteria in dental plaque through the anaerobic metabolism of sugars derived from the diet. The 2 primary bacteria involved in caries formation are mutans streptococci and lactobacilli. When sugars or other fermentable carbohydrates are ingested, the resulting fall in dental plaque pH caused by organic acids increases the solubility of calcium hydroxyapatite in the dental hard tissues and demineralization occurs as calcium is lost from the tooth surface. The pH at which demineralization occurs is often referred to as the critical pH and is approximately 5.5.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by bacteria
   H01331  Dental caries
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases or disorders of orofacial complex
   DA08  Diseases of hard tissues of teeth
    H01331  Dental caries
Pathogen
Streptococcus mutans [GN:smu smc smut smj]
Cryptobacterium curtum [GN:ccu]
Lactobacilli
Drug
Sodium fluoride [DR:D00943]
Stannous fluoride [DR:D05919]
Sodium fluoride and phosphoric acid [DR:D08736]
Other DBs
ICD-11: DA08.0
ICD-10: K02
MedlinePlus: 001055
MeSH: D003731
Reference
PMID:14972061 (description, env_factor, pathogen)
  Authors
Moynihan P, Petersen PE
  Title
Diet, nutrition and the prevention of dental diseases.
  Journal
Public Health Nutr 7:201-26 (2004)
DOI:10.1079/PHN2003589
Reference
PMID:14522753 (description, env_factor, pathogen)
  Authors
Touger-Decker R, van Loveren C
  Title
Sugars and dental caries.
  Journal
Am J Clin Nutr 78:881S-892S (2003)
DOI:10.1093/ajcn/78.4.881S
Reference
PMID:20331803 (pathogen)
  Authors
Piwat S, Teanpaisan R, Thitasomakul S, Thearmontree A, Dahlen G
  Title
Lactobacillus species and genotypes associated with dental caries in Thai preschool children.
  Journal
Mol Oral Microbiol 25:157-64 (2010)
DOI:10.1111/j.2041-1014.2009.00556.x
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