Entry |
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Name |
Atopic dermatitis |
Description |
Atopic dermatitis (AD) is a relapsing chronic inflammatory skin disease characterized by eczematous skin lesions and intense pruritus. A genetic defect in the filaggrin (FLG) protein and/or environmental factors are thought to cause AD by disrupting the epidermis. This disruption, in turn, results in contact between immune cells in the dermis and antigens from the external environment leading to intense itching, scratching, and inflammation. Apart from FLG, recent genome-wide association studies (GWASs) have identified many susceptibility loci of atopic dermatitis with genome-wide significance.
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Category |
Immune system disease
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Brite |
Human diseases [BR:br08402]
Immune system diseases
Allergies and autoimmune diseases
H01358 Atopic dermatitis
Skin diseases
Skin and soft tissue diseases
H01358 Atopic dermatitis
Human diseases in ICD-11 classification [BR:br08403]
14 Diseases of the skin
Inflammatory dermatoses
Dermatitis and eczema
EA80 Atopic eczema
H01358 Atopic dermatitis
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Gene |
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Env factor |
Soap
Detergent
Proteases from house dust mites
Topical corticosteroids
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Pathogen |
Staphylococcus aureus Malassezia sympodialis [GN: msym] |
Drug |
Triamcinolone acetonide [DR: D00983]
Dexamethasone [DR: D00292]
Dexamethasone sodium phosphate [DR: D00975]
Hydrocortisone [DR: D00088]
Hydrocortisone sodium succinate [DR: D00978]
Hydrocortisone butyrate [DR: D01619]
Prednisolone [DR: D00472]
Prednisolone sodium phosphate [DR: D00981]
Prednisone [DR: D00473]
Doxepin hydrochloride [DR: D00814]
Methylprednisolone [DR: D00407]
Methylprednisolone sodium succinate [DR: D00751]
Methylprednisolone acetate [DR: D00979]
Desonide [DR: D03696]
Tacrolimus [DR: D00107]
Pimecrolimus [DR: D05480]
Dupilumab [DR: D10354]
Crisaborole [DR: D10873]
Cortisone acetate [DR: D00973]
Hydroxyzine hydrochloride [DR: D00672]
Hydroxyzine pamoate [DR: D01096]
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Other DBs |
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Reference |
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Authors |
Kabashima K |
Title |
New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity. |
Journal |
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Reference |
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Authors |
Tamari M, Tanaka S, Hirota T |
Title |
Genome-wide association studies of allergic diseases. |
Journal |
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Reference |
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Authors |
Bussmann C, Weidinger S, Novak N |
Title |
Genetics of atopic dermatitis. |
Journal |
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Reference |
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Authors |
Barnes KC |
Title |
An update on the genetics of atopic dermatitis: scratching the surface in 2009. |
Journal |
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Reference |
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Authors |
Berke R, Singh A, Guralnick M |
Title |
Atopic dermatitis: an overview. |
Journal |
Am Fam Physician 86:35-42 (2012) |
Reference |
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Authors |
Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, MacGowan A, Duff GW, Ward SJ, Tazi-Ahnini R |
Title |
New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. |
Journal |
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Reference |
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Authors |
Cookson H, Smith C |
Title |
Systemic treatment of adult atopic dermatitis. |
Journal |
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Reference |
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Authors |
Simpson EL |
Title |
Atopic dermatitis: a review of topical treatment options. |
Journal |
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Reference |
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Authors |
Simon D, Bieber T |
Title |
Systemic therapy for atopic dermatitis. |
Journal |
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LinkDB |
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