KEGG   DISEASE: Eosinophilic esophagitis
Entry
H01361                      Disease                                

Name
Eosinophilic esophagitis
Description
Eosinophilic esophagitis (EoE) is a chronic immune and antigen-mediated clinicopathologic disease that is characterized by eosinophil infiltration into the esophageal epithelium and results in esophageal fibrosis and dysfunction. Several factors contribute to the development of EoE, including genetic predisposition, history of allergies, and presence of environmental and food allergens. Recently, an association between a single nuclear polymorphism (SNP) in the gene encoding thymic stromal lymphopoietin (TSLP) or eotaxin-3 (CCL-26) and risk for EoE was found.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01361  Eosinophilic esophagitis
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases of oesophagus
   DA24  Oesophagitis
    H01361  Eosinophilic esophagitis
Gene
TSLP (polymorphism) [HSA:85480] [KO:K05436]
CCL-26 (polymorphism) [HSA:10344] [KO:K21096]
Env factor
Milk
Wheat
Egg
Soy
Fish
Peanut
Dust mites
Aspergillus fumigatus [GN:afm]
Alternaria alternata
Ragweed pollen
Other DBs
ICD-11: DA24.1
MeSH: D057765
Reference
PMID:22313241 (gene, env_factor)
  Authors
Straumann A, Aceves SS, Blanchard C, Collins MH, Furuta GT, Hirano I, Schoepfer AM, Simon D, Simon HU
  Title
Pediatric and adult eosinophilic esophagitis: similarities and differences.
  Journal
Allergy 67:477-90 (2012)
DOI:10.1111/j.1398-9995.2012.02787.x
Reference
  Authors
Mulder DJ, Justinich CJ
  Title
Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease.
  Journal
Mucosal Immunol 4:139-47 (2011)
DOI:10.1038/mi.2010.88
Reference
  Authors
Blanchard C, Wang N, Rothenberg ME
  Title
Eosinophilic esophagitis: pathogenesis, genetics, and therapy.
  Journal
J Allergy Clin Immunol 118:1054-9 (2006)
DOI:10.1016/j.jaci.2006.07.038
Reference
  Authors
Merves J, Muir A, Modayur Chandramouleeswaran P, Cianferoni A, Wang ML, Spergel JM
  Title
Eosinophilic esophagitis.
  Journal
Ann Allergy Asthma Immunol 112:397-403 (2014)
DOI:10.1016/j.anai.2014.01.023
Reference
PMID:23130328 (env_factor)
  Authors
Ridolo E, Montagni M, Olivieri E, Rogkakou A, De' Angelis GL, Canonica GW
  Title
Eosinophilic esophagitis: which role for food and inhalant allergens?
  Journal
Asia Pac Allergy 2:237-41 (2012)
DOI:10.5415/apallergy.2012.2.4.237
Reference
PMID:21991511 (env_factor)
  Authors
Shahzad G, Mustacchia P, Frieri M
  Title
Role of mucosal inflammation in eosinophilic esophagitis: review of the literature.
  Journal
ISRN Gastroenterol 2011:468073 (2011)
DOI:10.5402/2011/468073
Reference
PMID:23001405 (drug, description)
  Authors
Redd M, Schey R
  Title
Eosinophilic esophagitis: current treatment.
  Journal
Dig Dis Sci 58:613-20 (2013)
DOI:10.1007/s10620-012-2383-1
Reference
PMID:22034864 (drug)
  Authors
Abonia JP, Rothenberg ME
  Title
Eosinophilic esophagitis: rapidly advancing insights.
  Journal
Annu Rev Med 63:421-34 (2012)
DOI:10.1146/annurev-med-041610-134138
Reference
(drug)
  Authors
Papadakis MA, McPhee SJ, Rabow MW (ed).
  Title
Current Medical Diagnosis & Treatment 2013, Fifty-Second Edition
  Journal
The McGraw-Hill Companies, Inc. (2013)
LinkDB

» Japanese version

DBGET integrated database retrieval system