KEGG   DISEASE: Dermatitis herpetiformis
Entry
H01362                      Disease                                

Name
Dermatitis herpetiformis
Description
Dermatitis herpetiformis (DH) is a chronic, polymorphic, pruritic skin disease that develops mostly in patients with latent gluten-sensitive enteropathy. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. Owing to the granular immunoglobulin (Ig) A deposition at the tips of the papillary dermis and to the subepidermal blister formation associated with neutrophilic accumulations underlying the basement membrane, DH is considered to be an autoimmune blistering disease.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01362  Dermatitis herpetiformis
 Skin diseases
  Skin and soft tissue diseases
   H01362  Dermatitis herpetiformis
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Inflammatory dermatoses
   Immunobullous diseases of the skin
    EB44  Dermatitis herpetiformis
     H01362  Dermatitis herpetiformis
Gene
HLA-DQA1 [HSA:3117] [KO:K06752]
HLA-DQB1 [HSA:3119] [KO:K06752]
HLA-DR3
HLA-B8
Env factor
Gluten
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Dapsone [DR:D00592]
Cortisone acetate [DR:D00973]
Other DBs
ICD-11: EB44
ICD-10: L13.0
Reference
PMID:22811741 (gene, env_factor)
  Authors
Nakajima K
  Title
Recent advances in dermatitis herpetiformis.
  Journal
Clin Dev Immunol 2012:914162 (2012)
DOI:10.1155/2012/914162
Reference
PMID:24068131 (gene, description, env_factor)
  Authors
Mendes FB, Hissa-Elian A, de Abreu MA, Goncalves VS
  Title
Review: dermatitis herpetiformis.
  Journal
An Bras Dermatol 88:594-9 (2013)
DOI:10.1590/abd1806-4841.20131775
Reference
PMID:22137227 (gene, description, env_factor)
  Authors
Karpati S
  Title
Dermatitis herpetiformis.
  Journal
Clin Dermatol 30:56-9 (2012)
DOI:10.1016/j.clindermatol.2011.03.010
Reference
PMID:21571168 (gene, drug)
  Authors
Bolotin D, Petronic-Rosic V
  Title
Dermatitis herpetiformis. Part II. Diagnosis, management, and prognosis.
  Journal
J Am Acad Dermatol 64:1027-33; quiz 1033-4 (2011)
DOI:10.1016/j.jaad.2010.09.776
Reference
PMID:23674144 (drug)
  Authors
Plotnikova N, Miller JL
  Title
Dermatitis herpetiformis.
  Journal
Skin Therapy Lett 18:1-3 (2013)
Reference
PMID:19470076 (drug)
  Authors
Caproni M, Antiga E, Melani L, Fabbri P
  Title
Guidelines for the diagnosis and treatment of dermatitis herpetiformis.
  Journal
J Eur Acad Dermatol Venereol 23:633-8 (2009)
DOI:10.1111/j.1468-3083.2009.03188.x
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