KEGG   DISEASE: Periodontal diseaseHelp
Entry
H01408                      Disease                                

Name
Periodontal disease
  Supergrp
Anaerobic infection [DS:H01410]
Description
During the early stages of the periodontal disease, saccharolytic, aerobic Streptococcus spp. and other bacteria adhere to and colonize the tooth enamel and root surface. This sets the stage for Fusobacterium nucleatum to coaggregate with these early colonizers and to permit late colonizers, including dental pathogens, to eventually form a biofilm. These complex interactions result in the release of factors that lead to tooth decay. Physical interaction is very specific among various genera in this complex microbial community. Due to the unusual length, adhesive nature, and other cell surface properties of F. nucleatum, periodontal disease-causing bacteria such as Porphyromonas gingivalis, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Treponema denticola, and Streptococcus spp. aggregate and thrive; hence, F. nucleatum is thought of as a 'bridge bacterium'.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by bacteria
   H01408  Periodontal disease
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases or disorders of orofacial complex
   DA0Z  Diseases or disorders of orofacial complex, unspecified
    H01408  Periodontal disease
BRITE hierarchy
Pathogen
Fusobacterium nucleatum [GN:fnu]
Porphyromonas gingivalis [GN:pgi pgn pgt]
Treponema denticola [GN:tde]
Treponema putidum [GN:tpk]
Treponema sp. OMZ 838 [GN:trm]
Aggregatibacter actinomycetemcomitans [GN:aat aan]
Olsenella uli [GN:ols]
Cryptobacterium curtum [GN:ccu]
Other DBs
ICD-11: DA0Z
ICD-10: K05
MeSH: D010510
Reference
  Authors
Kapatral V, Anderson I, Ivanova N, Reznik G, Los T, Lykidis A, Bhattacharyya A, Bartman A, Gardner W, Grechkin G, Zhu L, Vasieva O, Chu L, Kogan Y, Chaga O, Goltsman E, Bernal A, Larsen N, D'Souza M, Walunas T, Pusch G, Haselkorn R, Fonstein M, Kyrpides N, Overbeek R.
  Title
Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586.
  Journal
J Bacteriol 184:2005-18 (2002)
DOI:10.1128/JB.184.7.2005-2018.2002
Reference
PMID:12949112 (pathogen)
  Authors
Nelson KE, Fleischmann RD, DeBoy RT, Paulsen IT, Fouts DE, Eisen JA, Daugherty SC, Dodson RJ, Durkin AS, Gwinn M, Haft DH, Kolonay JF, Nelson WC, Mason T, Tallon L, Gray J, Granger D, Tettelin H, Dong H, Galvin JL, Duncan MJ, Dewhirst FE, Fraser CM.
  Title
Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83.
  Journal
J Bacteriol 185:5591-601 (2003)
DOI:10.1128/JB.185.18.5591-5601.2003
Reference
PMID:18524787 (pathogen)
  Authors
Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, Nakayama K, Toh H, Yoshimura F, Kuhara S, Hattori M, Hayashi T, Nakayama K.
  Title
Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis.
  Journal
DNA Res 15:215-25 (2008)
DOI:10.1093/dnares/dsn013
Reference
PMID:21705612 (pathogen)
  Authors
Watanabe T, Maruyama F, Nozawa T, Aoki A, Okano S, Shibata Y, Oshima K, Kurokawa K, Hattori M, Nakagawa I, Abiko Y
  Title
Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease.
  Journal
J Bacteriol 193:4259-60 (2011)
DOI:10.1128/JB.05269-11
Reference
PMID:15064399 (pathogen)
  Authors
Seshadri R, Myers GS, Tettelin H, Eisen JA, Heidelberg JF, Dodson RJ, Davidsen TM, DeBoy RT, Fouts DE, Haft DH, Selengut J, Ren Q, Brinkac LM, Madupu R, Kolonay J, Durkin SA, Daugherty SC, Shetty J, Shvartsbeyn A, Gebregeorgis E, Geer K, Tsegaye G, Malek J, Ayodeji B, Shatsman S, McLeod MP, Smajs D, Howell JK, Pal S, Amin A, Vashisth P, McNeill TZ, Xiang Q, Sodergren E, Baca E, Weinstock GM, Norris SJ, Fraser CM, Paulsen IT.
  Title
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.
  Journal
Proc Natl Acad Sci U S A 101:5646-51 (2004)
DOI:10.1073/pnas.0307639101
Reference
  Authors
Thiha K, Takeuchi Y, Umeda M, Huang Y, Ohnishi M, Ishikawa I
  Title
Identification of periodontopathic bacteria in gingival tissue of Japanese periodontitis patients.
  Journal
Oral Microbiol Immunol 22:201-7 (2007)
DOI:10.1111/j.1399-302X.2007.00354.x
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