KEGG   DISEASE: Methicillin-sensitive Staphylococcus aureus (MSSA) infectionHelp
Entry
H01409                      Disease                                

Name
Methicillin-sensitive Staphylococcus aureus (MSSA) infection
Description
Staphylococcus aureus is a Gram-positive human commensal bacterium persistently colonizing the anterior nares of about 30% of the human population. Methicillin-resistant S. aureus (MRSA) is known to have evolved from methicillin-susceptible S. aureus (MSSA) after acquiring the staphylococcal cassette chromosome mec (SCCmec) element which includes the mecA gene coding for resistance to the antibiotic methicillin. A highly cytotoxic and clinically virulent methicillin-sensitive strain, S. aureus strain 6850 is a well-characterized prototype strain isolated from a patient with a skin abscess which had progressed to S. aureus bacteremia, osteomyelitis, septic arthritis, and multiple systemic abscesses.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by Gram-positive bacteria
   H01409  Methicillin-sensitive Staphylococcus aureus (MSSA) infection
BRITE hierarchy
Pathway
hsa05150  Staphylococcus aureus infection
Pathogen
Staphylococcus aureus [GN:sas suc sud saue]
Drug
Quinupristin and dalfopristin [DR:D00854]
Other DBs
ICD-10: B95
MeSH: D013203
Reference
  Authors
Fraunholz M, Bernhardt J, Schuldes J, Daniel R, Hecker M, Sinha B
  Title
Complete Genome Sequence of Staphylococcus aureus 6850, a Highly Cytotoxic and Clinically Virulent Methicillin-Sensitive Strain with Distant Relatedness to Prototype Strains.
  Journal
Genome Announc 1:e00775-13 (2013)
DOI:10.1128/genomeA.00775-13
Reference
  Authors
Lim KT, Yeo CC, Suhaili Z, Thong KL
  Title
Comparison of methicillin-resistant and methicillin-sensitive Staphylococcus aureus strains isolated from a tertiary hospital in Terengganu, Malaysia.
  Journal
Jpn J Infect Dis 65:502-9 (2012)
DOI:10.7883/yoken.65.502
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