KEGG   DISEASE: Ulcerative colitisHelp
H01466                      Disease                                

Ulcerative colitis
Inflammatory bowel disease (IBD) [DS:H01227]
Ulcerative colitis (UC) is one subtype of inflammatory bowel disease (IBD) whose pathogenesis is multifactorial and includes influences from genes, the environment, and the gut microbiome. In UC the inflammatory is limited to the musoca of the colon and rectum. Clinically, the most common manifestation of UC may include bloody diarrhea, abdominal pain. In most severe cases, patients may experience fever, weight loss, anemia, and the intestine can get distended, presenting deep ulceration and possibly intestinal perforation.The long-time duration of the disease increases a colorectal caner risk. UC is associated with a Th2 immune response. Recent genetic analyses have linked genes including interleukin 23 receptor, interleukin 10 and macrophage stimulating 1.
Immune system disease
Human diseases [BR:br08402]
 Immune system diseases
  Other immune system diseases
   H01466  Ulcerative colitis
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Inflammatory bowel diseases
   DD71  Ulcerative colitis
    H01466  Ulcerative colitis
BRITE hierarchy
hsa04060 Cytokine-cytokine receptor interaction   
hsa04630 Jak-STAT signaling pathway   
hsa05321 Inflammatory bowel disease   
IL23R (polymorphism) [HSA:149233] [KO:K05065]
IL10 (polymorphism) [HSA:3586] [KO:K05443]
MST1 (polymorphism) [HSA:4485] [KO:K23441]
Fusobacterium varium [GN:fva]
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone acetate [DR:D00165]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Budesonide [DR:D00246]
Sulfasalazine [DR:D00448]
Mesalamine [DR:D00377]
Olsalazine sodium [DR:D00727]
Balsalazide disodium [DR:D02715]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Cortisone acetate [DR:D00973]
Vedolizumab [DR:D08083]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Golimumab [DR:D04358]
Other DBs
ICD-11: DD71
ICD-10: K51
MeSH: D003093
OMIM: 612261 612241 612381
PMID:26339135 (description and drug)
de Mattos BR, Garcia MP, Nogueira JB, Paiatto LN, Albuquerque CG, Souza CL, Fernandes LG, Tamashiro WM, Simioni PU
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.
Mediators Inflamm 2015:493012 (2015)
Abraham C, Cho JH
Inflammatory bowel disease.
N Engl J Med 361:2066-78 (2009)
Pang YH, Zheng CQ, Yang XZ, Zhang WJ
Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.
Cell Immunol 248:115-20 (2007)
Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, Mathew CG, Schreiber S
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
Nat Genet 40:1319-23 (2008)
PMID:26600980 (drug)
Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y, Fukawa K, Esaki M, Niina Y, Ogino H
Promising biological therapies for ulcerative colitis: A review of the literature.
World J Gastrointest Pathophysiol 6:219-27 (2015)
PMID:26284562 (drug)
Danese S, Vuitton L, Peyrin-Biroulet L
Biologic agents for IBD: practical insights.
Nat Rev Gastroenterol Hepatol 12:537-45 (2015)
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