KEGG   DISEASE: Ulcerative colitisHelp
Entry
H01466                      Disease                                

Name
Ulcerative colitis
  Supergrp
Inflammatory bowel disease (IBD) [DS:H01227]
Description
Ulcerative colitis (UC) is one subtype of inflammatory bowel disease (IBD) whose pathogenesis is multifactorial and includes influences from genes, the environment, and the gut microbiome. In UC the inflammatory is limited to the musoca of the colon and rectum. Clinically, the most common manifestation of UC may include bloody diarrhea, abdominal pain. In most severe cases, patients may experience fever, weight loss, anemia, and the intestine can get distended, presenting deep ulceration and possibly intestinal perforation.The long-time duration of the disease increases a colorectal caner risk. UC is associated with a Th2 immune response. Recent genetic analyses have linked genes including interleukin 23 receptor, interleukin 10 and macrophage stimulating 1.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Other immune system diseases
   H01466  Ulcerative colitis
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Inflammatory bowel diseases
   DD71  Ulcerative colitis
    H01466  Ulcerative colitis
BRITE hierarchy
Pathway
hsa04060 Cytokine-cytokine receptor interaction   
hsa04630 Jak-STAT signaling pathway   
hsa05321 Inflammatory bowel disease   
Gene
IL23R (polymorphism) [HSA:149233] [KO:K05065]
IL10 (polymorphism) [HSA:3586] [KO:K05443]
MST1 (polymorphism) [HSA:4485] [KO:K23441]
Pathogen
Fusobacterium varium [GN:fva]
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone acetate [DR:D00165]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Budesonide [DR:D00246]
Sulfasalazine [DR:D00448]
Mesalamine [DR:D00377]
Olsalazine sodium [DR:D00727]
Balsalazide disodium [DR:D02715]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Cortisone acetate [DR:D00973]
Vedolizumab [DR:D08083]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Golimumab [DR:D04358]
Other DBs
ICD-11: DD71
ICD-10: K51
MeSH: D003093
OMIM: 612261 612241 612381
Reference
PMID:26339135 (description and drug)
  Authors
de Mattos BR, Garcia MP, Nogueira JB, Paiatto LN, Albuquerque CG, Souza CL, Fernandes LG, Tamashiro WM, Simioni PU
  Title
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.
  Journal
Mediators Inflamm 2015:493012 (2015)
DOI:10.1155/2015/493012
Reference
  Authors
Abraham C, Cho JH
  Title
Inflammatory bowel disease.
  Journal
N Engl J Med 361:2066-78 (2009)
DOI:10.1056/NEJMra0804647
Reference
  Authors
Pang YH, Zheng CQ, Yang XZ, Zhang WJ
  Title
Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.
  Journal
Cell Immunol 248:115-20 (2007)
DOI:10.1016/j.cellimm.2007.10.003
Reference
  Authors
Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, Mathew CG, Schreiber S
  Title
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
  Journal
Nat Genet 40:1319-23 (2008)
DOI:10.1038/ng.221
Reference
PMID:26600980 (drug)
  Authors
Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y, Fukawa K, Esaki M, Niina Y, Ogino H
  Title
Promising biological therapies for ulcerative colitis: A review of the literature.
  Journal
World J Gastrointest Pathophysiol 6:219-27 (2015)
DOI:10.4291/wjgp.v6.i4.219
Reference
PMID:26284562 (drug)
  Authors
Danese S, Vuitton L, Peyrin-Biroulet L
  Title
Biologic agents for IBD: practical insights.
  Journal
Nat Rev Gastroenterol Hepatol 12:537-45 (2015)
DOI:10.1038/nrgastro.2015.135
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