KEGG   DISEASE: Multidrug-resistant tuberculosis
Entry
H01472                      Disease                                

Name
Multidrug-resistant tuberculosis
  Supergrp
Tuberculosis [DS:H00342]
Description
Multi-drug-resistant tuberculosis is generally defined as infection with M. tuberculosis strains that are resistant to isoniazid and rifampin, the first-line antibiotics for treating tuberculosis. Drug-resistant tuberculosis has reached new levels of concern because of the recent identification of strains that are resistant not only to rifampin and isoniazid but also to any fluoroquinolone and at least 1 of the second-line injectable agents (amikacin, kanamycin, and capreomycin); this type of drug-resistant tuberculosis has been designated extensively drug-resistant tuberculosis.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by actinobacteria
   H01472  Multidrug-resistant tuberculosis
Human diseases in ICD-11 classification [BR:br08403]
 21 Symptoms, signs or clinical findings, not elsewhere classified
  General symptoms, signs or clinical findings
   Finding of microorganism resistant to antimicrobial drugs
    MG52  Finding of bacteria, neither gram negative nor positive, resistant to antimicrobial drugs
     H01472  Multidrug-resistant tuberculosis
Pathogen
Mycobacterium tuberculosis [GN:mtl]
Drug
Bedaquiline fumarate [DR:D09873]
Pretomanid [DR:D10722]
Other DBs
ICD-11: MG52.00
ICD-10: U84.3 U84.7
MeSH: D018088
Reference
  Authors
Millard J, Ugarte-Gil C, Moore DA
  Title
Multidrug resistant tuberculosis.
  Journal
BMJ 350:h882 (2015)
DOI:10.1136/bmj.h882
Reference
  Authors
Chan ED, Strand MJ, Iseman MD
  Title
Multidrug-resistant tuberculosis (TB) resistant to fluoroquinolones and streptomycin but susceptible to second-line injection therapy has a better prognosis than extensively drug-resistant TB.
  Journal
Clin Infect Dis 48:e50-2 (2009)
DOI:10.1086/597010
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