KEGG   DISEASE: Seronegative arthritisHelp
Entry
H01507                      Disease                                

Name
Seronegative arthritis
  Subgroup
Ankylosing spondylosis
Undifferentiated spondylarthritis
Reactive arthritis
Psoriatic arthritis
Enteropathic arthritis
Description
Seronegative spondyloarthropathies (SpA) represent a group of chronic articular inflammatory diseases which differ from rheumatoid arthritis for the typical absence of rheumatoid factor in serum, and have in common several epidemiological, pathological, clinical, and radiological features. SpA include ankylosing spondylitis (AS), reactive arthritis (ReA), enteropathic (IBD) associated arthritis, psoriatic arthritis (PsA), as well as undifferentiated, and juvenile SpA. The main clinical manifestations include inflammatory back pain, peripheral arthritis, enthesitis, and extra-skeletal manifestations, such as uveitis. Although the cause of SpA is unknown, it is generally accepted that SpA is a multifactorial disease. Genetics (such as HLA-B27), inflammatory cytokines (such as TNF), and more recently the IL-23/IL-17 cytokine pathway have links to pathogenesis. Biologic agents, particularly TNF blockers, are primary treatment options and have been shown to reduce symptomatic inflammation.
Category
Musculoskeletal disease
Brite
Human diseases [BR:br08402]
 Musculoskeletal diseases
  Other musculoskeletal diseases
   H01507  Seronegative arthritis
BRITE hierarchy
Gene
HLA-B [HSA:3106] [KO:K06751]
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Cortisone acetate [DR:D00973]
Abatacept [DR:D03203]
Apremilast [DR:D08860]
Etanercept [DR:D00742]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Certolizumab pegol [DR:D03441]
Golimumab [DR:D04358]
Ustekinumab [DR:D09214]
Secukinumab [DR:D09967]
Other DBs
MeSH: D025241
OMIM: 106300
Reference
  Authors
Paparo F, Revelli M, Semprini A, Camellino D, Garlaschi A, Cimmino MA, Rollandi GA, Leone A
  Title
Seronegative spondyloarthropathies: what radiologists should know.
  Journal
Radiol Med 119:156-63 (2014)
DOI:10.1007/s11547-013-0316-5
Reference
  Authors
Wilson G, Folzenlogen DD
  Title
Spondyloarthropathies: new directions in etiopathogenesis, diagnosis and treatment.
  Journal
Mo Med 109:69-74 (2012)
Reference
  Authors
Melis L, Elewaut D
  Title
Progress in spondylarthritis. Immunopathogenesis of spondyloarthritis: which cells drive disease?
  Journal
Arthritis Res Ther 11:233 (2009)
DOI:10.1186/ar2722
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