KEGG   DISEASE: Gout
Entry
H01532                      Disease                                

Name
Gout
Description
Gout is a kind of arthritis associated with hyperuricemia. It is triggered due to precipitation and deposition of inflammatory monosodium urate crystals in synovial and other tissues, accompanied by severe pain. The most common symptom include swelling, tenderness, warmth and redness. Mostly, the joint at the base of the big toe is affected, gout progresses with more frequent attacks that involve multiple joints. Joint pain that used to resolve in a week to 10 days could become a milder, but constant pain. Eventually, untreated gout can cause other comorbidities such as high blood pressure, diabetes, chronic kidney disease and cardiovascular disease. The incidence of the disease is more common in 40s men than women, but gout in women after menopause appears increased risk. Recently, the onset in 20s increases. The development of gout is not only associated with sex, age, race and genetics, but also diet and lifestyle are contributed to increasing prevalence of the disease. Epidemiology studies reported that the excessive intake of alcohol and purine rich food, which excessively produce uric acid, leads to accumulation of uric acid.
Category
Musculoskeletal disease
Brite
Human diseases [BR:br08402]
 Musculoskeletal diseases
  Other musculoskeletal diseases
   H01532  Gout
Human diseases in ICD-11 classification [BR:br08403]
 15 Diseases of the musculoskeletal system or connective tissue
  Arthropathies
   Inflammatory arthropathies
    FA25  Gout
     H01532  Gout
Pathway
hsa00230  Purine metabolism
Env factor
Alcohol, Purine rich food, Fructose/Sugar-sweetened beverages
Drug
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Indomethacin [DR:D00141]
Naproxen [DR:D00118]
Naproxen sodium [DR:D00970]
Cortisone acetate [DR:D00973]
Allopurinol [DR:D00224]
Febuxostat [DR:D01206]
Lesinurad and allopurinol [DR:D11175]
Probenecid [DR:D00475]
Lesinurad [DR:D09921]
Colchicine [DR:D00570]
Pegloticase [DR:D09316]
Probenecid and colchicine [DR:D11574]
Other DBs
ICD-11: FA25
ICD-10: M10
MeSH: D006073
Reference
PMID:25151572 (description and drug)
  Authors
Dalbeth N, Lauterio TJ, Wolfe HR
  Title
Mechanism of action of colchicine in the treatment of gout.
  Journal
Clin Ther 36:1465-79 (2014)
DOI:10.1016/j.clinthera.2014.07.017
Reference
PMID:21894471 (description and drug)
  Authors
Sunkureddi P
  Title
Gouty arthritis: understanding the disease state and management options in primary care.
  Journal
Adv Ther 28:748-60 (2011)
DOI:10.1007/s12325-011-0058-5
Reference
PMID:26977282 (drug)
  Authors
Bernal JA, Quilis N, Andres M, Sivera F, Pascual E
  Title
Gout: optimizing treatment to achieve a disease cure.
  Journal
Ther Adv Chronic Dis 7:135-44 (2016)
DOI:10.1177/2040622315618393
Reference
  Authors
MacFarlane LA, Kim SC
  Title
Gout: a review of nonmodifiable and modifiable risk factors.
  Journal
Rheum Dis Clin North Am 40:581-604 (2014)
DOI:10.1016/j.rdc.2014.07.002
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