Entry |
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Name |
Fallopian tube cancer |
Description |
Fallopian tube cancer is a rare, aggressive gynecologic malignancy. Recent genetic and immunohistochemical studies strongly suggest that high-grade serous adenocarcinoma (SAC) involving the ovary likely arises from distal fallopian tube epithelium, indicating that some ovarian cancers develop in the fallopian tube and are then spread to the ovary. Fallopian tube cancers are similar to ovarian cancer with respect to the proportion of tumors with abnormal expression of c-erbB-2 and p53. It has been proposed that the p53 signature is the earliest step in the pathogenesis of fallopian tube cancer. In this model, tubal epithelium on the fimbria experiences genotoxic damage and, as a result, the secretory cell exhibits over-accumulation of p53 protein (p53 signature). There is also some evidence that BRCA-1 and BRCA-2 mutations and c-myc have a major role in tumorgenesis.
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Category |
Cancer
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Brite |
Human diseases [BR:br08402]
Cancers
Cancers of the breast and female genital organs
H01554 Fallopian tube cancer
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Malignant neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms of female genital organs
2C74 Malignant neoplasms of fallopian tube
H01554 Fallopian tube cancer
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Gene |
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Drug |
Bevacizumab [DR: D06409]
Niraparib tosilate hydrate [DR: D11895]
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Other DBs |
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Reference |
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Authors |
Horng HC, Teng SW, Huang BS, Sun HD, Yen MS, Wang PH, Tsui KH, Wen KC, Chen YJ, Chuang CM, Chao HT, Chang WH |
Title |
Primary fallopian tube cancer: domestic data and up-to-date review. |
Journal |
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Reference |
PMID: 23622731 (description, gene, marker, drug) |
Authors |
Kalampokas E, Kalampokas T, Tourountous I |
Title |
Primary fallopian tube carcinoma. |
Journal |
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Reference |
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Authors |
Nik NN, Vang R, Shih IeM, Kurman RJ |
Title |
Origin and pathogenesis of pelvic (ovarian, tubal, and primary peritoneal) serous carcinoma. |
Journal |
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Reference |
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Authors |
Haruta S, Furukawa N, Yoshizawa Y, Tsunemi T, Nagai A, Kawaguchi R, Tanase Y, Yoshida S, Kobayashi H |
Title |
Molecular genetics and epidemiology of epithelial ovarian cancer (Review). |
Journal |
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Reference |
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Authors |
Sama AR, Schilder RJ |
Title |
Refractory fallopian tube carcinoma - current perspectives in pathogenesis and management. |
Journal |
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Reference |
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Authors |
Lacy MQ, Hartmann LC, Keeney GL, Cha SC, Wieand HS, Podratz KC, Roche PC |
Title |
c-erbB-2 and p53 expression in fallopian tube carcinoma. |
Journal |
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Reference |
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Authors |
Vang R, Shih IeM, Kurman RJ |
Title |
Fallopian tube precursors of ovarian low- and high-grade serous neoplasms. |
Journal |
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Reference |
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Authors |
Keating GM |
Title |
Bevacizumab: a review of its use in advanced cancer. |
Journal |
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LinkDB |
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