KEGG   DISEASE: Autoimmune hemolytic anemia
Entry
H01585                      Disease                                

Name
Autoimmune hemolytic anemia
Description
Autoimmune hemolytic anemia (AIHA) is a relatively uncommon disorder caused by the increased destruction of red blood cells (RBCs) by anti-RBC autoantibodies with or without complement activation. AIHAs can be distinguished on the basis of the autoantibody Ig class and thermal characteristics, i.e. the optimal temperature of reaction with autologous erythrocytes, in warm (wAIHA), cold (cold agglutinin disease; CAD), and mixed forms, although atypical cases of difficult diagnostic classification are reported with increasing frequency. Moreover, AIHAs are classified in primary (idiopathic), in which hemolysis dominates the clinical picture in the absence of any other coexisting disorder, and in secondary forms, accompanying and complicating an underlying disease. AIHA may develop gradually, or have a fulminant onset with life-threatening anemia. The diagnosis is usually simple, based on the presence of hemolytic anemia and serological evidence of anti-erythrocyte antibodies, detectable by the direct antiglobulin test (DAT).
Category
Hematologic disease; Immune system disease
Brite
Human diseases [BR:br08402]
 Cardiovascular diseases
  Hematologic diseases
   H01585  Autoimmune hemolytic anemia
Human diseases in ICD-11 classification [BR:br08403]
 03 Diseases of the blood or blood-forming organs
  Anaemias or other erythrocyte disorders
   Haemolytic anaemias
    Acquired haemolytic anaemia
     3A20  Acquired haemolytic anaemia, immune
      H01585  Autoimmune hemolytic anemia
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Cortisone acetate [DR:D00973]
Other DBs
ICD-11: 3A20
ICD-10: D59.0 D59.1
MeSH: D000744
Reference
  Authors
Barcellini W
  Title
New Insights in the Pathogenesis of Autoimmune Hemolytic Anemia.
  Journal
Transfus Med Hemother 42:287-93 (2015)
DOI:10.1159/000439002
Reference
  Authors
Zanella A, Barcellini W
  Title
Treatment of autoimmune hemolytic anemias.
  Journal
Haematologica 99:1547-54 (2014)
DOI:10.3324/haematol.2014.114561
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