KEGG   DISEASE: Restless legs syndrome
Entry
H01597                      Disease                                

Name
Restless legs syndrome;
Willis Ekbom disease
Description
The restless legs syndrome (RLS), also known as Willis Ekbom disease is a neurologic disorder characterized by unpleasant sensations in the legs accompanied by an urge to move them (akathisia). These symptoms occur predominantly at rest and worsen at night, resulting in nocturnal insomnia and chronic sleep deprivation. The prevalence of RLS increases with age and appears to be higher among women than among men. RLS has a high familial aggregation. To date, several loci and genetic risk factors have been identified, but no causative gene mutation has been found. Standard medications for RLS are dopamine agonists and CACN alpha-2 delta blocker. A high prevalence of iron deficiency has been found among patients with RLS. It has been reported that treatment with oral iron supplements resulted in improvements in the severity of the symptoms in patients with a low serum ferritin level.
Category
Nervous system disease
Brite
Human diseases [BR:br08402]
 Nervous system diseases
  Other nervous and sensory system diseases
   H01597  Restless legs syndrome
Human diseases in ICD-11 classification [BR:br08403]
 07 Sleep-wake disorders
  Sleep-related movement disorders
   7A80  Restless legs syndrome
    H01597  Restless legs syndrome
Drug
Gabapentin enacarbil [DR:D09539]
Ropinirole hydrochloride [DR:D00784]
Pramipexole dihydrochloride [DR:D00559]
Rotigotine [DR:D05768]
Other DBs
ICD-11: 7A80
ICD-10: G25.8
MeSH: D012148
OMIM: 102300
Reference
  Authors
Earley CJ
  Title
Clinical practice. Restless legs syndrome.
  Journal
N Engl J Med 348:2103-9 (2003)
DOI:10.1056/NEJMcp021288
Reference
  Authors
Weissbach A, Siegesmund K, Bruggemann N, Schmidt A, Kasten M, Pichler I, Muhle H, Lohmann E, Lohnau T, Schwinger E, Hagenah J, Stephani U, Pramstaller PP, Klein C, Lohmann K
  Title
Exome sequencing in a family with restless legs syndrome.
  Journal
Mov Disord 27:1686-9 (2012)
DOI:10.1002/mds.25191
Reference
PMID:27224246 (drug)
  Authors
Ferini-Strambi L, Marelli S, Galbiati A
  Title
Clinical pharmacology and efficacy of rotigotine (Neupro(R) patch) in the treatment of restless leg syndrome.
  Journal
Expert Opin Drug Metab Toxicol 1-9 (2016)
DOI:10.1080/17425255.2016.1194393
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